Search Results

Overview

Uniprot ID	Q9Y4I1
Protein Name	Unconventional myosin-Va
Gene Name	MYO5A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
55	LEYHLDPKTKELPHL
556	IIQHFADKVEYQCEG
994	SLQEEIAKLRKDLEQ

Function

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity)

Protein Sequence

10 MAASELYTKF 20 ARVWIPDPEE 30 VWKSAELLKD 40 YKPGDKVLLL 50 HLEEGKDLEY 60 HLDPKTKELP 70 HLRNPDILVG 80 ENDLTALSYL 90 HEPAVLHNLR 100 VRFIDSKLIY 110 TYCGIVLVAI 120 NPYEQLPIYG 130 EDIINAYSGQ 140 NMGDMDPHIF 150 AVAEEAYKQM 160 ARDERNQSII 170 VSGESGAGKT 180 VSAKYAMRYF 190 ATVSGSASEA 200 NVEEKVLASN 210 PIMESIGNAK 220 TTRNDNSSRF 230 GKYIEIGFDK 240 RYRIIGANMR 250 TYLLEKSRVV 260 FQAEEERNYH 270 IFYQLCASAK 280 LPEFKMLRLG 290 NADNFNYTKQ 300 GGSPVIEGVD 310 DAKEMAHTRQ 320 ACTLLGISES 330 HQMGIFRILA 340 GILHLGNVGF 350 TSRDADSCTI 360 PPKHEPLCIF 370 CELMGVDYEE 380 MCHWLCHRKL 390 ATATETYIKP 400 ISKLQATNAR 410 DALAKHIYAK 420 LFNWIVDNVN 430 QALHSAVKQH 440 SFIGVLDIYG 450 FETFEINSFE 460 QFCINYANEK 470 LQQQFNMHVF 480 KLEQEEYMKE 490 QIPWTLIDFY 500 DNQPCINLIE 510 SKLGILDLLD 520 EECKMPKGTD 530 DTWAQKLYNT 540 HLNKCALFEK 550 PRLSNKAFII 560 QHFADKVEYQ 570 CEGFLEKNKD 580 TVFEEQIKVL 590 KSSKFKMLPE 600 LFQDDEKAIS 610 PTSATSSGRT 620 PLTRTPAKPT 630 KGRPGQMAKE 640 HKKTVGHQFR 650 NSLHLLMETL 660 NATTPHYVRC 670 IKPNDFKFPF 680 TFDEKRAVQQ 690 LRACGVLETI 700 RISAAGFPSR 710 WTYQEFFSRY 720 RVLMKQKDVL 730 SDRKQTCKNV 740 LEKLILDKDK 750 YQFGKTKIFF 760 RAGQVAYLEK 770 LRADKLRAAC 780 IRIQKTIRGW 790 LLRKKYLRMR 800 KAAITMQRYV 810 RGYQARCYAK 820 FLRRTKAATI 830 IQKYWRMYVV 840 RRRYKIRRAA 850 TIVLQSYLRG 860 FLARNRYRKI 870 LREHKAVIIQ 880 KRVRGWLART 890 HYKRSMHAII 900 YLQCCFRRMM 910 AKRELKKLKI 920 EARSVERYKK 930 LHIGMENKIM 940 QLQRKVDEQN 950 KDYKCLVEKL 960 TNLEGIYNSE 970 TEKLRSDLER 980 LQLSEEEAKV 990 ATGRVLSLQE 1000 EIAKLRKDLE 1010 QTRSEKKCIE 1020 EHADRYKQET 1030 EQLVSNLKEE 1040 NTLLKQEKEA 1050 LNHRIVQQAK 1060 EMTETMEKKL 1070 VEETKQLELD 1080 LNDERLRYQN 1090 LLNEFSRLEE 1100 RYDDLKEEMT 1110 LMVHVPKPGH 1120 KRTDSTHSSN 1130 ESEYIFSSEI 1140 AEMEDIPSRT 1150 EEPSEKKVPL 1160 DMSLFLKLQK 1170 RVTELEQEKQ 1180 VMQDELDRKE 1190 EQVLRSKAKE 1200 EERPQIRGAE 1210 LEYESLKRQE 1220 LESENKKLKN 1230 ELNELRKALS 1240 EKSAPEVTAP 1250 GAPAYRVLME 1260 QLTSVSEELD 1270 VRKEEVLILR 1280 SQLVSQKEAI 1290 QPKDDKNTMT 1300 DSTILLEDVQ 1310 KMKDKGEIAQ 1320 AYIGLKETNR 1330 SSALDYHELN 1340 EDGELWLVYE 1350 GLKQANRLLE 1360 SQLQSQKRSH 1370 ENEAEALRGE 1380 IQSLKEENNR 1390 QQQLLAQNLQ 1400 LPPEARIEAS 1410 LQHEITRLTN 1420 ENLDLMEQLE 1430 KQDKTVRKLK 1440 KQLKVFAKKI 1450 GELEVGQMEN 1460 ISPGQIIDEP 1470 IRPVNIPRKE 1480 KDFQGMLEYK 1490 KEDEQKLVKN 1500 LILELKPRGV 1510 AVNLIPGLPA 1520 YILFMCVRHA 1530 DYLNDDQKVR 1540 SLLTSTINSI 1550 KKVLKKRGDD 1560 FETVSFWLSN 1570 TCRFLHCLKQ 1580 YSGEEGFMKH 1590 NTSRQNEHCL 1600 TNFDLAEYRQ 1610 VLSDLAIQIY 1620 QQLVRVLENI 1630 LQPMIVSGML 1640 EHETIQGVSG 1650 VKPTGLRKRT 1660 SSIADEGTYT 1670 LDSILRQLNS 1680 FHSVMCQHGM 1690 DPELIKQVVK 1700 QMFYIIGAIT 1710 LNNLLLRKDM 1720 CSWSKGMQIR 1730 YNVSQLEEWL 1740 RDKNLMNSGA 1750 KETLEPLIQA 1760 AQLLQVKKKT 1770 DDDAEAICSM 1780 CNALTTAQIV 1790 KVLNLYTPVN 1800 EFEERVSVSF 1810 IRTIQMRLRD 1820 RKDSPQLLMD 1830 AKHIFPVTFP 1840 FNPSSLALET 1850 IQIPASLGLG FISRV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0032433	filopodium tip
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0032593	insulin-responsive compartment
Cellular Component	GO:0042470	melanosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0016459	myosin complex
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0001726	ruffle
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0000146	microfilament motor activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0007015	actin filament organization
Biological Process	GO:0030048	actin filament-based movement
Biological Process	GO:0032869	cellular response to insulin stimulus
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0032402	melanosome transport
Biological Process	GO:0006892	post-Golgi vesicle-mediated transport
Biological Process	GO:0072659	protein localization to plasma membrane
Biological Process	GO:0015031	protein transport
Biological Process	GO:0030050	vesicle transport along actin filament
Biological Process	GO:0016192	vesicle-mediated transport

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.