Search Results

Overview

Uniprot IDQ9Y4L1
Protein NameHypoxia up-regulated protein 1
Gene NameHYOU1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 YFQHLLGKQADNPHV
398 RVQEVLLKAVGKEEL
433 LSKAFKVKPFVVRDA
463 EPGIHSLKHNKRVLF
62 PMEIVLNKESRRKTP
67 LNKESRRKTPVIVTL
685 APAPEGEKKQKPARK
722 KLAQSVQKLQDLTLR
75 TPVIVTLKENERFFG
797 TTVMLKEKLAELRKL
803 EKLAELRKLCQGLFF
883 AKLPATEKPVLLSKD
889 EKPVLLSKDIEAKMM
908 EVQYLLNKAKFTKPR
91 SAASMAIKNPKATLR
910 QYLLNKAKFTKPRPR

Function

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding

Protein Sequence

10 MADKVRRQRP 20 RRRVCWALVA 30 VLLADLLALS 40 DTLAVMSVDL 50 GSESMKVAIV 60 KPGVPMEIVL 70 NKESRRKTPV 80 IVTLKENERF 90 FGDSAASMAI 100 KNPKATLRYF 110 QHLLGKQADN 120 PHVALYQARF 130 PEHELTFDPQ 140 RQTVHFQISS 150 QLQFSPEEVL 160 GMVLNYSRSL 170 AEDFAEQPIK 180 DAVITVPVFF 190 NQAERRAVLQ 200 AARMAGLKVL 210 QLINDNTATA 220 LSYGVFRRKD 230 INTTAQNIMF 240 YDMGSGSTVC 250 TIVTYQMVKT 260 KEAGMQPQLQ 270 IRGVGFDRTL 280 GGLEMELRLR 290 ERLAGLFNEQ 300 RKGQRAKDVR 310 ENPRAMAKLL 320 REANRLKTVL 330 SANADHMAQI 340 EGLMDDVDFK 350 AKVTRVEFEE 360 LCADLFERVP 370 GPVQQALQSA 380 EMSLDEIEQV 390 ILVGGATRVP 400 RVQEVLLKAV 410 GKEELGKNIN 420 ADEAAAMGAV 430 YQAAALSKAF 440 KVKPFVVRDA 450 VVYPILVEFT 460 REVEEEPGIH 470 SLKHNKRVLF 480 SRMGPYPQRK 490 VITFNRYSHD 500 FNFHINYGDL 510 GFLGPEDLRV 520 FGSQNLTTVK 530 LKGVGDSFKK 540 YPDYESKGIK 550 AHFNLDESGV 560 LSLDRVESVF 570 ETLVEDSAEE 580 ESTLTKLGNT 590 ISSLFGGGTT 600 PDAKENGTDT 610 VQEEEESPAE 620 GSKDEPGEQV 630 ELKEEAEAPV 640 EDGSQPPPPE 650 PKGDATPEGE 660 KATEKENGDK 670 SEAQKPSEKA 680 EAGPEGVAPA 690 PEGEKKQKPA 700 RKRRMVEEIG 710 VELVVLDLPD 720 LPEDKLAQSV 730 QKLQDLTLRD 740 LEKQEREKAA 750 NSLEAFIFET 760 QDKLYQPEYQ 770 EVSTEEQREE 780 ISGKLSAAST 790 WLEDEGVGAT 800 TVMLKEKLAE 810 LRKLCQGLFF 820 RVEERKKWPE 830 RLSALDNLLN 840 HSSMFLKGAR 850 LIPEMDQIFT 860 EVEMTTLEKV 870 INETWAWKNA 880 TLAEQAKLPA 890 TEKPVLLSKD 900 IEAKMMALDR 910 EVQYLLNKAK 920 FTKPRPRPKD 930 KNGTRAEPPL 940 NASASDQGEK 950 VIPPAGQTED 960 AEPISEPEKV 970 ETGSEPGDTE 980 PLELGGPGAE 990 PEQKEQSTGQ KRPLKNDEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071682 endocytic vesicle lumen
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0034663 endoplasmic reticulum chaperone complex
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005790 smooth endoplasmic reticulum
Molecular Function GO:0000774 adenyl-nucleotide exchange factor activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0051087 protein-folding chaperone binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
Biological Process GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0002931 response to ischemia

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.