Search Results
Overview
| Uniprot ID | Q9Y4R8 |
|---|---|
| Protein Name | Telomere length regulation protein TEL2 homolog |
| Gene Name | TELO2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 678 | SKTQRLSKGGPRQGP |
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation
Protein Sequence
10
MEPAPSEVRL
20
AVREAIHALS
30
SSEDGGHIFC
40
TLESLKRYLG
50
EMEPPALPRE
60
KEEFASAHFS
70
PVLRCLASRL
80
SPAWLELLPH
90
GRLEELWASF
100
FLEGPADQAF
110
LVLMETIEGA
120
AGPSFRLMKM
130
ARLLARFLRE
140
GRLAVLMEAQ
150
CRQQTQPGFI
160
LLRETLLGKV
170
VALPDHLGNR
180
LQQENLAEFF
190
PQNYFRLLGE
200
EVVRVLQAVV
210
DSLQGGLDSS
220
VSFVSQVLGK
230
ACVHGRQQEI
240
LGVLVPRLAA
250
LTQGSYLHQR
260
VCWRLVEQVP
270
DRAMEAVLTG
280
LVEAALGPEV
290
LSRLLGNLVV
300
KNKKAQFVMT
310
QKLLFLQSRL
320
TTPMLQSLLG
330
HLAMDSQRRP
340
LLLQVLKELL
350
ETWGSSSAIR
360
HTPLPQQRHV
370
SKAVLICLAQ
380
LGEPELRDSR
390
DELLASMMAG
400
VKCRLDSSLP
410
PVRRLGMIVA
420
EVVSARIHPE
430
GPPLKFQYEE
440
DELSLELLAL
450
ASPQPAGDGA
460
SEAGTSLVPA
470
TAEPPAETPA
480
EIVDGGVPQA
490
QLAGSDSDLD
500
SDDEFVPYDM
510
SGDRELKSSK
520
APAYVRDCVE
530
ALTTSEDIER
540
WEAALRALEG
550
LVYRSPTATR
560
EVSVELAKVL
570
LHLEEKTCVV
580
GFAGLRQRAL
590
VAVTVTDPAP
600
VADYLTSQFY
610
ALNYSLRQRM
620
DILDVLTLAA
630
QELSRPGCLG
640
RTPQPGSPSP
650
NTPCLPEAAV
660
SQPGSAVASD
670
WRVVVEERIR
680
SKTQRLSKGG
690
PRQGPAGSPS
700
RFNSVAGHFF
710
FPLLQRFDRP
720
LVTFDLLGED
730
QLVLGRLAHT
740
LGALMCLAVN
750
TTVAVAMGKA
760
LLEFVWALRF
770
HIDAYVRQGL
780
LSAVSSVLLS
790
LPAARLLEDL
800
MDELLEARSW
810
LADVAEKDPD
820
EDCRTLALRA
830
LLLLQRLKNR
LLPPASP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0140777 | protein-containing complex stabilizing activity |
| Molecular Function | GO:0042162 | telomeric DNA binding |
| Biological Process | GO:0051083 | 'de novo' cotranslational protein folding |
| Biological Process | GO:2000003 | positive regulation of DNA damage checkpoint |
| Biological Process | GO:0050821 | protein stabilization |
Reference
PMID: N/A