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Overview

Uniprot IDQ9Y4W2
Protein NameRibosomal biogenesis protein LAS1L
Gene NameLAS1L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
135 ERKTKFAKVPLKCLA
139 KFAKVPLKCLAQEVN

Function

Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961)

Protein Sequence

10 MSWESGAGPG 20 LGSQGMDLVW 30 SAWYGKCVKG 40 KGSLPLSAHG 50 IVVAWLSRAE 60 WDQVTVYLFC 70 DDHKLQRYAL 80 NRITVWRSRS 90 GNELPLAVAS 100 TADLIRCKLL 110 DVTGGLGTDE 120 LRLLYGMALV 130 RFVNLISERK 140 TKFAKVPLKC 150 LAQEVNIPDW 160 IVDLRHELTH 170 KKMPHINDCR 180 RGCYFVLDWL 190 QKTYWCRQLE 200 NSLRETWELE 210 EFREGIEEED 220 QEEDKNIVVD 230 DITEQKPEPQ 240 DDGKSTESDV 250 KADGDSKGSE 260 EVDSHCKKAL 270 SHKELYERAR 280 ELLVSYEEEQ 290 FTVLEKFRYL 300 PKAIKAWNNP 310 SPRVECVLAE 320 LKGVTCENRE 330 AVLDAFLDDG 340 FLVPTFEQLA 350 ALQIEYEDGQ 360 TEVQRGEGTD 370 PKSHKNVDLN 380 DVLVPKPFSQ 390 FWQPLLRGLH 400 SQNFTQALLE 410 RMLSELPALG 420 ISGIRPTYIL 430 RWTVELIVAN 440 TKTGRNARRF 450 SAGQWEARRG 460 WRLFNCSASL 470 DWPRMVESCL 480 GSPCWASPQL 490 LRIIFKAMGQ 500 GLPDEEQEKL 510 LRICSIYTQS 520 GENSLVQEGS 530 EASPIGKSPY 540 TLDSLYWSVK 550 PASSSFGSEA 560 KAQQQEEQGS 570 VNDVKEEEKE 580 EKEVLPDQVE 590 EEEENDDQEE 600 EEEDEDDEDD 610 EEEDRMEVGP 620 FSTGQESPTA 630 ENARLLAQKR 640 GALQGSAWQV 650 SSEDVRWDTF 660 PLGRMPGQTE 670 DPAELMLENY 680 DTMYLLDQPV 690 LEQRLEPSTC 700 KTDTLGLSCG 710 VGSGNCSNSS 720 SSNFEGLLWS 730 QGQLHGLKTG LQLF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0090730 Las1 complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0071339 MLL1 complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004519 endonuclease activity
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000460 maturation of 5.8S rRNA
Biological Process GO:0000470 maturation of LSU-rRNA
Biological Process GO:0006364 rRNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.