Search Results
Overview
| Uniprot ID | Q9Y4Y9 |
|---|---|
| Protein Name | U6 snRNA-associated Sm-like protein LSm5 |
| Gene Name | LSM5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 20 | LPLELVDKCIGSRIH |
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320)
Protein Sequence
10
MAANATTNPS
20
QLLPLELVDK
30
CIGSRIHIVM
40
KSDKEIVGTL
50
LGFDDFVNMV
60
LEDVTEFEIT
70
PEGRRITKLD
80
QILLNGNNIT
90
MLVPGGEGPE
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:1990726 | Lsm1-7-Pat1 complex |
| Cellular Component | GO:0120115 | Lsm2-8 complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Cellular Component | GO:0005688 | U6 snRNP |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| Biological Process | GO:0006402 | mRNA catabolic process |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0000387 | spliceosomal snRNP assembly |
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
Reference
PMID: N/A