Search Results

Overview

Uniprot IDQ9Y520
Protein NameProtein PRRC2C
Gene NamePRRC2C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1017 VRRSGPIKKPVLRDM
16 TKAKDGKKYATLSLF
1724 KGRSQTSKLPPRFAK
2007 AVLNDISKKLGPISP
2100 AGPIKAQKLPDLSPV
2119 HKPGPIGKERSLKNR
2255 FKMESARKAWENSPN
229 ACGPPQAKLNGQQAA
2701 SPNSQSSKMNSIVYQ
2832 FSEQQQSKQIGGGKA
29 LFNTYKGKSLETQKT
387 PAQPSVAKVPYGKGP
392 VAKVPYGKGPSFNQE
47 HGLQSLGKVGISRRM
484 RKAACAEKLKRLDEK
983 SEGPKPEKVYKSKSE

Function

Required for efficient formation of stress granules

Protein Sequence

10 MSEKSGQSTK 20 AKDGKKYATL 30 SLFNTYKGKS 40 LETQKTTARH 50 GLQSLGKVGI 60 SRRMPPPANL 70 PSLKAENKGN 80 DPNVNIVPKD 90 GTGWASKQEQ 100 HEEEKTPEVP 110 PAQPKPGVAA 120 PPEVAPAPKS 130 WASNKQGGQG 140 DGIQVNSQFQ 150 QEFPSLQAAG 160 DQEKKEKETN 170 DDNYGPGPSL 180 RPPNVACWRD 190 GGKAAGSPSS 200 SDQDEKLPGQ 210 DESTAGTSEQ 220 NDILKVVEKR 230 IACGPPQAKL 240 NGQQAALASQ 250 YRAMMPPYMF 260 QQYPRMTYPP 270 LHGPMRFPPS 280 LSETNKGLRG 290 RGPPPSWASE 300 PERPSILSAS 310 ELKELDKFDN 320 LDAEADEGWA 330 GAQMEVDYTE 340 QLNFSDDDEQ 350 GSNSPKENNS 360 EDQGSKASEN 370 NENKKETDEV 380 SNTKSSSQIP 390 AQPSVAKVPY 400 GKGPSFNQER 410 GTSSHLPPPP 420 KLLAQQHPPP 430 DRQAVPGRPG 440 PFPSKQQVAD 450 EDEIWKQRRR 460 QQSEISAAVE 470 RARKRREEEE 480 RRMEEQRKAA 490 CAEKLKRLDE 500 KLGILEKQPS 510 PEEIRERERE 520 KEREREKELE 530 KEQEQEREKE 540 REKDRERQQE 550 KEKELEKEQE 560 KQREMEKERK 570 QEKEKELERQ 580 KEKEKELQKM 590 KEQEKECELE 600 KEREKLEEKI 610 EPREPNLEPM 620 VEKQESENSC 630 NKEEEPVFTR 640 QDSNRSEKEA 650 TPVVHETEPE 660 SGSQPRPAVL 670 SGYFKQFQKS 680 LPPRFQRQQE 690 QMKQQQWQQQ 700 QQQGVLPQTV 710 PSQPSSSTVP 720 PPPHRPLYQP 730 MQPHPQHLAS 740 MGFDPRWLMM 750 QSYMDPRMMS 760 GRPAMDIPPI 770 HPGMIPPKPL 780 MRRDQMEGSP 790 NSSESFEHIA 800 RSARDHAISL 810 SEPRMLWGSD 820 PYPHAEPQQA 830 TTPKATEEPE 840 DVRSEAALDQ 850 EQITAAYSVE 860 HNQLEAHPKA 870 DFIRESSEAQ 880 VQKFLSRSVE 890 DVRPHHTDAN 900 NQSACFEAPD 910 QKTLSAPQEE 920 RISAVESQPS 930 RKRSVSHGSN 940 HTQKPDEQRS 950 EPSAGIPKVT 960 SRCIDSKEPI 970 ERPEEKPKKE 980 GFIRSSEGPK 990 PEKVYKSKSE 1000 TRWGPRPSSN 1010 RREEVNDRPV 1020 RRSGPIKKPV 1030 LRDMKEEREQ 1040 RKEKEGEKAE 1050 KVTEKVVVKP 1060 EKTEKKDLPP 1070 PPPPPQPPAP 1080 IQPQSVPPPI 1090 QPEAEKFPST 1100 ETATLAQKPS 1110 QDTEKPLEPV 1120 STVQVEPAVK 1130 TVNQQTMAAP 1140 VVKEEKQPEK 1150 VISKDLVIER 1160 PRPDSRPAVK 1170 KESTLPPRTY 1180 WKEARERDWF 1190 PDQGYRGRGR 1200 GEYYSRGRSY 1210 RGSYGGRGRG 1220 GRGHTRDYPQ 1230 YRDNKPRAEH 1240 IPSGPLRQRE 1250 ESETRSESSD 1260 FEVVPKRRRQ 1270 RGSETDTDSE 1280 IHESASDKDS 1290 LSKGKLPKRE 1300 ERPENKKPVK 1310 PHSSFKPDNH 1320 VRIDNRLLEK 1330 PYVRDDDKAK 1340 PGFLPKGEPT 1350 RRGRGGTFRR 1360 GGRDPGGRPS 1370 RPSTLRRPAY 1380 RDNQWNPRQS 1390 EVPKPEDGEP 1400 PRRHEQFIPI 1410 AADKRPPKFE 1420 RKFDPARERP 1430 RRQRPTRPPR 1440 QDKPPRFRRL 1450 REREAASKSN 1460 EVVAVPTNGT 1470 VNNVAQEPVN 1480 TLGDISGNKT 1490 PDLSNQNSSD 1500 QANEEWETAS 1510 ESSDFNERRE 1520 RDEKKNADLN 1530 AQTVVKVGEN 1540 VLPPKREIAK 1550 RSFSSQRPVD 1560 RQNRRGNNGP 1570 PKSGRNFSGP 1580 RNERRSGPPS 1590 KSGKRGPFDD 1600 QPAGTTGVDL 1610 INGSSAHHQE 1620 GVPNGTGQKN 1630 SKDSTGKKRE 1640 DPKPGPKKPK 1650 EKVDALSQFD 1660 LNNYASVVII 1670 DDHPEVTVIE 1680 DPQSNLNDDG 1690 FTEVVSKKQQ 1700 KRLQDEERRK 1710 KEEQVIQVWN 1720 KKNANEKGRS 1730 QTSKLPPRFA 1740 KKQATGIQQA 1750 QSSASVPPLA 1760 SAPLPPSTSA 1770 SVPASTSAPL 1780 PATLTPVPAS 1790 TSAPVPASTL 1800 APVLASTSAP 1810 VPASPLAPVS 1820 ASASVSASVP 1830 ASTSAAAITS 1840 SSAPASAPAP 1850 TPILASVSTP 1860 ASVTILASAS 1870 IPILASALAS 1880 TSAPTPAPAA 1890 SSPAAPVITA 1900 PTIPASAPTA 1910 SVPLAPASAS 1920 APAPAPTPVS 1930 APNPAPPAPA 1940 QTQAQTHKPV 1950 QNPLQTTSQS 1960 SKQPPPSIRL 1970 PSAQTPNGTD 1980 YVASGKSIQT 1990 PQSHGTLTAE 2000 LWDNKVAPPA 2010 VLNDISKKLG 2020 PISPPQPPSV 2030 SAWNKPLTSF 2040 GSAPSSEGAK 2050 NGQESGLEIG 2060 TDTIQFGAPA 2070 SNGNENEVVP 2080 VLSEKSADKI 2090 PEPKEQRQKQ 2100 PRAGPIKAQK 2110 LPDLSPVENK 2120 EHKPGPIGKE 2130 RSLKNRKVKD 2140 AQQVEPEGQE 2150 KPSPATVRST 2160 DPVTTKETKA 2170 VSEMSTEIGT 2180 MISVSSAEYG 2190 TNAKESVTDY 2200 TTPSSSLPNT 2210 VATNNTKMED 2220 TLVNNVPLPN 2230 TLPLPKRETI 2240 QQSSSLTSVP 2250 PTTFSLTFKM 2260 ESARKAWENS 2270 PNVREKGSPV 2280 TSTAPPIATG 2290 VSSSASGPST 2300 ANYNSFSSAS 2310 MPQIPVASVT 2320 PTASLSGAGT 2330 YTTSSLSTKS 2340 TTTSDPPNIC 2350 KVKPQQLQTS 2360 SLPSASHFSQ 2370 LSCMPSLIAQ 2380 QQQNPQVYVS 2390 QSAAAQIPAF 2400 YMDTSHLFNT 2410 QHARLAPPSL 2420 AQQQGFQPGL 2430 SQPTSVQQIP 2440 IPIYAPLQGQ 2450 HQAQLSLGAG 2460 PAVSQAQELF 2470 SSSLQPYRSQ 2480 PAFMQSSLSQ 2490 PSVVLSGTAI 2500 HNFPTVQHQE 2510 LAKAQSGLAF 2520 QQTSNTQPIP 2530 ILYEHQLGQA 2540 SGLGGSQLID 2550 THLLQARANL 2560 TQASNLYSGQ 2570 VQQPGQTNFY 2580 NTAQSPSALQ 2590 QVTVPLPASQ 2600 LSLPNFGSTG 2610 QPLIALPQTL 2620 QPPLQHTTPQ 2630 AQAQSLSRPA 2640 QVSQPFRGLI 2650 PAGTQHSMIA 2660 TTGKMSEMEL 2670 KAFGSGIDIK 2680 PGTPPIAGRS 2690 TTPTSSPFRA 2700 TSTSPNSQSS 2710 KMNSIVYQKQ 2720 FQSAPATVRM 2730 TQPFPTQFAP 2740 QILSQPNLVP 2750 PLVRAPHTNT 2760 FPAPVQRPPM 2770 ALASQMPPPL 2780 TTGLMSHARL 2790 PHVARGPCGS 2800 LSGVRGNQAQ 2810 AALKAEQDMK 2820 AKQRAEVLQS 2830 TQRFFSEQQQ 2840 SKQIGGGKAQ 2850 KVDSDSSKPP 2860 ETLTDPPGVC 2870 QEKVEEKPPP 2880 APSIATKPVR 2890 TGPIKPQAIK TEETKS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0010494 cytoplasmic stress granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Molecular Function GO:0003723 RNA binding
Biological Process GO:0002244 hematopoietic progenitor cell differentiation
Biological Process GO:0034063 stress granule assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.