Search Results

Overview

Uniprot IDQ9Y570
Protein NameProtein phosphatase methylesterase 1
Gene NamePPME1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
270 EGSESISKRKKEDDM
30 GGSQSGAKMRMGPGR
328 AGVDRLDKDLTIGQM
6 **MSALEKSMHLGRL

Function

Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme

Protein Sequence

10 MSALEKSMHL 20 GRLPSRPPLP 30 GSGGSQSGAK 40 MRMGPGRKRD 50 FSPVPWSQYF 60 ESMEDVEVEN 70 ETGKDTFRVY 80 KSGSEGPVLL 90 LLHGGGHSAL 100 SWAVFTAAII 110 SRVQCRIVAL 120 DLRSHGETKV 130 KNPEDLSAET 140 MAKDVGNVVE 150 AMYGDLPPPI 160 MLIGHSMGGA 170 IAVHTASSNL 180 VPSLLGLCMI 190 DVVEGTAMDA 200 LNSMQNFLRG 210 RPKTFKSLEN 220 AIEWSVKSGQ 230 IRNLESARVS 240 MVGQVKQCEG 250 ITSPEGSKSI 260 VEGIIEEEEE 270 DEEGSESISK 280 RKKEDDMETK 290 KDHPYTWRIE 300 LAKTEKYWDG 310 WFRGLSNLFL 320 SCPIPKLLLL 330 AGVDRLDKDL 340 TIGQMQGKFQ 350 MQVLPQCGHA 360 VHEDAPDKVA 370 EAVATFLIRH 380 RFAEPIGGFQ CVFPGC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0106222 lncRNA binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0051723 protein methylesterase activity
Molecular Function GO:0051721 protein phosphatase 2A binding
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0004864 protein phosphatase inhibitor activity
Biological Process GO:0000086 G2/M transition of mitotic cell cycle

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.