Search Results

Overview

Uniprot ID	Q9Y5A7
Protein Name	NEDD8 ultimate buster 1
Gene Name	NUB1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
159	KAMVLELKQSEEDAR
198	RGLEILAKRAAETVV

Function

Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2

Protein Sequence

10 MAQKKYLQAK 20 LTQFLREDRI 30 QLWKPPYTDE 40 NKKVGLALKD 50 LAKQYSDRLE 60 CCENEVEKVI 70 EEIRCKAIER 80 GTGNDNYRTT 90 GIATIEVFLP 100 PRLKKDRKNL 110 LETRLHITGR 120 ELRSKIAETF 130 GLQENYIKIV 140 INKKQLQLGK 150 TLEEQGVAHN 160 VKAMVLELKQ 170 SEEDARKNFQ 180 LEEEEQNEAK 190 LKEKQIQRTK 200 RGLEILAKRA 210 AETVVDPEMT 220 PYLDIANQTG 230 RSIRIPPSER 240 KALMLAMGYH 250 EKGRAFLKRK 260 EYGIALPCLL 270 DADKYFCECC 280 RELLDTVDNY 290 AVLQLDIVWC 300 YFRLEQLECL 310 DDAEKKLNLA 320 QKCFKNCYGE 330 NHQRLVHIKG 340 NCGKEKVLFL 350 RLYLLQGIRN 360 YHSGNDVEAY 370 EYLNKARQLF 380 KELYIDPSKV 390 DNLLQLGFTA 400 QEARLGLRAC 410 DGNVDHAATH 420 ITNRREELAQ 430 IRKEEKEKKR 440 RRLENIRFLK 450 GMGYSTHAAQ 460 QVLHAASGNL 470 DEALKILLSN 480 PQMWWLNDSN 490 PETDNRQESP 500 SQENIDRLVY 510 MGFDALVAEA 520 ALRVFRGNVQ 530 LAAQTLAHNG 540 GSLPPELPLS 550 PEDSLSPPAT 560 SPSDSAGTSS 570 ASTDEDMETE 580 AVNEILEDIP 590 EHEEDYLDST 600 LEDEEIIIAE 610 YLSYVENRKS ATKKN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0097413	Lewy body
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:0010498	proteasomal protein catabolic process
Biological Process	GO:0016567	protein ubiquitination
Biological Process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process
Biological Process	GO:0034612	response to tumor necrosis factor
Biological Process	GO:0034341	response to type II interferon
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.