Search Results

Overview

Uniprot IDQ9Y5B0
Protein NameRNA polymerase II subunit A C-terminal domain phosphatase
Gene NameCTDP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
283 ECIDPFSKTGNLRNL
780 IYDSNTGKLIRTGAR

Function

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation

Protein Sequence

10 MEVPAAGRVP 20 AEGAPTAAVA 30 EVRCPGPAPL 40 RLLEWRVAAG 50 AAVRIGSVLA 60 VFEAAASAQS 70 SGASQSRVAS 80 GGCVRPARPE 90 RRLRSERAGV 100 VRELCAQPGQ 110 VVAPGAVLVR 120 LEGCSHPVVM 130 KGLCAECGQD 140 LTQLQSKNGK 150 QQVPLSTATV 160 SMVHSVPELM 170 VSSEQAEQLG 180 REDQQRLHRN 190 RKLVLMVDLD 200 QTLIHTTEQH 210 CQQMSNKGIF 220 HFQLGRGEPM 230 LHTRLRPHCK 240 DFLEKIAKLY 250 ELHVFTFGSR 260 LYAHTIAGFL 270 DPEKKLFSHR 280 ILSRDECIDP 290 FSKTGNLRNL 300 FPCGDSMVCI 310 IDDREDVWKF 320 APNLITVKKY 330 VYFQGTGDMN 340 APPGSRESQT 350 RKKVNHSRGT 360 EVSEPSPPVR 370 DPEGVTQAPG 380 VEPSNGLEKP 390 ARELNGSEAA 400 TPRDSPRPGK 410 PDERDIWPPA 420 QAPTSSQELA 430 GAPEPQGSCA 440 QGGRVAPGQR 450 PAQGATGTDL 460 DFDLSSDSES 470 SSESEGTKSS 480 SSASDGESEG 490 KRGRQKPKAA 500 PEGAGALAQG 510 SSLEPGRPAA 520 PSLPGEAEPG 530 AHAPDKEPEL 540 GGQEEGERDG 550 LCGLGNGCAD 560 RKEAETESQN 570 SELSGVTAGE 580 SLDQSMEEEE 590 EEDTDEDDHL 600 IYLEEILVRV 610 HTDYYAKYDR 620 YLNKEIEEAP 630 DIRKIVPELK 640 SKVLADVAII 650 FSGLHPTNFP 660 IEKTREHYHA 670 TALGAKILTR 680 LVLSPDAPDR 690 ATHLIAARAG 700 TEKVLQAQEC 710 GHLHVVNPDW 720 LWSCLERWDK 730 VEEQLFPLRD 740 DHTKAQRENS 750 PAAFPDREGV 760 PPTALFHPMP 770 VLPKAQPGPE 780 VRIYDSNTGK 790 LIRTGARGPP 800 APSSSLPIRQ 810 EPSSFRAVPP 820 PQPQMFGEEL 830 PDAQDGEQPG 840 PSRRKRQPSM 850 SETMPLYTLC 860 KEDLESMDKE 870 VDDILGEGSD 880 DSDSEKRRPE 890 EQEEEPQPRK 900 PGTRRERTLG 910 APASSERSAA 920 GGRGPRGHKR 930 KLNEEDAASE 940 SSRESSNEDE 950 GSSSEADEMA 960 KALEAELNDL M

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0030496 midbody
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0005819 spindle
Cellular Component GO:0051233 spindle midzone
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0004721 phosphoprotein phosphatase activity
Molecular Function GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity
Molecular Function GO:0030957 Tat protein binding
Molecular Function GO:0001096 TFIIF-class transcription factor complex binding
Biological Process GO:0051301 cell division
Biological Process GO:0010458 exit from mitosis
Biological Process GO:0043923 host-mediated activation of viral transcription
Biological Process GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0006368 transcription elongation by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.