Search Results

Overview

Uniprot ID	Q9Y5B6
Protein Name	PAX3- and PAX7-binding protein 1
Gene Name	PAXBP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
133	SYSKKIVKLLKKEYK
145	EYKEDLEKSKIKTEL
841	KQWFMNLKGERTISQ
911	DHNVKEFKSLIEGK*
99	RKRPRENKEVPRASL

Function

Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20

Protein Sequence

10 MFRKARRVNV 20 RKRNDSEEEE 30 RERDEEQEPP 40 PLLPPPGTGE 50 EAGPGGGDRA 60 PGGESLLGPG 70 PSPPSALTPG 80 LGAEAGGGFP 90 GGAEPGNGLK 100 PRKRPRENKE 110 VPRASLLSFQ 120 DEEEENEEVF 130 KVKKSSYSKK 140 IVKLLKKEYK 150 EDLEKSKIKT 160 ELNSSAESEQ 170 PLDKTGHVKD 180 TNQEDGVIIS 190 EHGEDEMDME 200 SEKEEEKPKT 210 GGAFSNALSS 220 LNVLRPGEIP 230 DAAFIHAARK 240 KRQMARELGD 250 FTPHDNEPGK 260 GRLVREDEND 270 ASDDEDDDEK 280 RRIVFSVKEK 290 SQRQKIAEEI 300 GIEGSDDDAL 310 VTGEQDEELS 320 RWEQEQIRKG 330 INIPQVQASQ 340 PAEVNMYYQN 350 TYQTMPYGSS 360 YGIPYSYTAY 370 GSSDAKSQKT 380 DNTVPFKTPS 390 NEMTPVTIDL 400 VKKQLKDRLD 410 SMKELHKTNR 420 QQHEKHLQSR 430 VDSTRAIERL 440 EGSSGGIGER 450 YKFLQEMRGY 460 VQDLLECFSE 470 KVPLINELES 480 AIHQLYKQRA 490 SRLVQRRQDD 500 IKDESSEFSS 510 HSNKALMAPN 520 LDSFGRDRAL 530 YQEHAKRRIA 540 EREARRTRRR 550 QAREQTGKMA 560 DHLEGLSSDD 570 EETSTDITNF 580 NLEKDRISKE 590 SGKVFEDVLE 600 SFYSIDCIKS 610 QFEAWRSKYY 620 TSYKDAYIGL 630 CLPKLFNPLI 640 RLQLLTWTPL 650 EAKCRDFENM 660 LWFESLLFYG 670 CEEREQEKDD 680 VDVALLPTIV 690 EKVILPKLTV 700 IAENMWDPFS 710 TTQTSRMVGI 720 TLKLINGYPS 730 VVNAENKNTQ 740 VYLKALLLRM 750 RRTLDDDVFM 760 PLYPKNVLEN 770 KNSGPYLFFQ 780 RQFWSSVKLL 790 GNFLQWYGIF 800 SNKTLQELSI 810 DGLLNRYILM 820 AFQNSEYGDD 830 SIKKAQNVIN 840 CFPKQWFMNL 850 KGERTISQLE 860 NFCRYLVHLA 870 DTIYRNSIGC 880 SDVEKRNARE 890 NIKQIVKLLA 900 SVRALDHAMS 910 VASDHNVKEF KSLIEGK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:1990226	histone methyltransferase binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:0007517	muscle organ development
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.