Overview
| Uniprot ID | Q9Y5B8 |
|---|
| Protein Name | Nucleoside diphosphate kinase 7 |
|---|
| Gene Name | NME7 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 131 |
KMMMLSRKEALDFHV |
Function
Possesses an intrinsic kinase activity (PubMed:24807905, PubMed:34764205). Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling (PubMed:34764205). Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing (PubMed:16313181). In vitro, does not seem to have nucleoside diphosphate kinase activity (PubMed:16313181, PubMed:24807905). Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner (PubMed:24807905). May maintain primary cilium assembly and ciliary microtubule stability (PubMed:39824631). Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating (PubMed:36191189)
Protein Sequence
10
MNHSERFVFI
20
AEWYDPNASL
30
LRRYELLFYP
40
GDGSVEMHDV
50
KNHRTFLKRT
60
KYDNLHLEDL
70
FIGNKVNVFS
80
RQLVLIDYGD
90
QYTARQLGSR
100
KEKTLALIKP
110
DAISKAGEII
120
EIINKAGFTI
130
TKLKMMMLSR
140
KEALDFHVDH
150
QSRPFFNELI
160
QFITTGPIIA
170
MEILRDDAIC
180
EWKRLLGPAN
190
SGVARTDASE
200
SIRALFGTDG
210
IRNAAHGPDS
220
FASAAREMEL
230
FFPSSGGCGP
240
ANTAKFTNCT
250
CCIVKPHAVS
260
EGLLGKILMA
270
IRDAGFEISA
280
MQMFNMDRVN
290
VEEFYEVYKG
300
VVTEYHDMVT
310
EMYSGPCVAM
320
EIQQNNATKT
330
FREFCGPADP
340
EIARHLRPGT
350
LRAIFGKTKI
360
QNAVHCTDLP
370
EDGLLEVQYF
FKILDN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0160111 |
axonemal A tubule inner sheath |
| Molecular Function |
GO:0008296 |
3'-5'-DNA exonuclease activity |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004672 |
protein kinase activity |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Biological Process |
GO:0060271 |
cilium assembly |
| Biological Process |
GO:0006241 |
CTP biosynthetic process |
| Biological Process |
GO:0006308 |
DNA catabolic process |
| Biological Process |
GO:0030317 |
flagellated sperm motility |
| Biological Process |
GO:0006183 |
GTP biosynthetic process |
| Biological Process |
GO:0010968 |
regulation of microtubule nucleation |
| Biological Process |
GO:0006228 |
UTP biosynthetic process |
| Cellular Component |
GO:0005879 |
axonemal microtubule |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0005929 |
cilium |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000931 |
gamma-tubulin ring complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0036126 |
sperm flagellum |
| Cellular Component |
GO:0005819 |
spindle |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.