Search Results
Overview
| Uniprot ID | Q9Y5J1 |
|---|---|
| Protein Name | U3 small nucleolar RNA-associated protein 18 homolog |
| Gene Name | UTP18 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 166 | RFRKDMMKNASESKL |
| 172 | MKNASESKLSKDNLK |
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA
Protein Sequence
10
MPPERRRRMK
20
LDRRTGAKPK
30
RKPGMRPDWK
40
AGAGPGGPPQ
50
KPAPSSQRKP
60
PARPSAAAAA
70
IAVAAAEEER
80
RLRQRNRLRL
90
EEDKPAVERC
100
LEELVFGDVE
110
NDEDALLRRL
120
RGPRVQEHED
130
SGDSEVENEA
140
KGNFPPQKKP
150
VWVDEEDEDE
160
EMVDMMNNRF
170
RKDMMKNASE
180
SKLSKDNLKK
190
RLKEEFQHAM
200
GGVPAWAETT
210
KRKTSSDDES
220
EEDEDDLLQR
230
TGNFISTSTS
240
LPRGILKMKN
250
CQHANAERPT
260
VARISSVQFH
270
PGAQIVMVAG
280
LDNAVSLFQV
290
DGKTNPKIQS
300
IYLERFPIFK
310
ACFSANGEEV
320
LATSTHSKVL
330
YVYDMLAGKL
340
IPVHQVRGLK
350
EKIVRSFEVS
360
PDGSFLLING
370
IAGYLHLLAM
380
KTKELIGSMK
390
INGRVAASTF
400
SSDSKKVYAS
410
SGDGEVYVWD
420
VNSRKCLNRF
430
VDEGSLYGLS
440
IATSRNGQYV
450
ACGSNCGVVN
460
IYNQDSCLQE
470
TNPKPIKAIM
480
NLVTGVTSLT
490
FNPTTEILAI
500
ASEKMKEAVR
510
LVHLPSCTVF
520
SNFPVIKNKN
530
ISHVHTMDFS
540
PRSGYFALGN
550
EKGKALMYRL
HHYSDF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome |
| Cellular Component | GO:0032040 | small-subunit processome |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0030490 | maturation of SSU-rRNA |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
Reference
PMID: N/A