Search Results
Overview
| Uniprot ID | Q9Y5K5 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase isozyme L5 |
| Gene Name | UCHL5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 282 | VQKLKRYKIENIRRK |
Function
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1
Protein Sequence
10
MTGNAGEWCL
20
MESDPGVFTE
30
LIKGFGCRGA
40
QVEEIWSLEP
50
ENFEKLKPVH
60
GLIFLFKWQP
70
GEEPAGSVVQ
80
DSRLDTIFFA
90
KQVINNACAT
100
QAIVSVLLNC
110
THQDVHLGET
120
LSEFKEFSQS
130
FDAAMKGLAL
140
SNSDVIRQVH
150
NSFARQQMFE
160
FDTKTSAKEE
170
DAFHFVSYVP
180
VNGRLYELDG
190
LREGPIDLGA
200
CNQDDWISAV
210
RPVIEKRIQK
220
YSEGEIRFNL
230
MAIVSDRKMI
240
YEQKIAELQR
250
QLAEEEPMDT
260
DQGNSMLSAI
270
QSEVAKNQML
280
IEEEVQKLKR
290
YKIENIRRKH
300
NYLPFIMELL
310
KTLAEHQQLI
320
PLVEKAKEKQ
NAKKAQETK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031011 | Ino80 complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000502 | proteasome complex |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Molecular Function | GO:0004866 | endopeptidase inhibitor activity |
| Molecular Function | GO:0070628 | proteasome binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0048853 | forebrain morphogenesis |
| Biological Process | GO:0021670 | lateral ventricle development |
| Biological Process | GO:0030901 | midbrain development |
| Biological Process | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0045739 | positive regulation of DNA repair |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045880 | positive regulation of smoothened signaling pathway |
| Biological Process | GO:1904507 | positive regulation of telomere maintenance in response to DNA damage |
| Biological Process | GO:0016579 | protein deubiquitination |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0033044 | regulation of chromosome organization |
| Biological Process | GO:0006275 | regulation of DNA replication |
| Biological Process | GO:0060382 | regulation of DNA strand elongation |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0061136 | regulation of proteasomal protein catabolic process |
| Biological Process | GO:0000723 | telomere maintenance |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.