Search Results

Overview

Uniprot IDQ9Y5L0
Protein NameTransportin-3
Gene NameTNPO3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
881 NSLKGLPKETTVGAV

Function

Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914)

Protein Sequence

10 MEGAKPTLQL 20 VYQAVQALYH 30 DPDPSGKERA 40 SFWLGELQRS 50 VHAWEISDQL 60 LQIRQDVESC 70 YFAAQTMKMK 80 IQTSFYELPT 90 DSHASLRDSL 100 LTHIQNLKDL 110 SPVIVTQLAL 120 AIADLALQMP 130 SWKGCVQTLV 140 EKYSNDVTSL 150 PFLLEILTVL 160 PEEVHSRSLR 170 IGANRRTEII 180 EDLAFYSSTV 190 VSLLMTCVEK 200 AGTDEKMLMK 210 VFRCLGSWFN 220 LGVLDSNFMA 230 NNKLLALLFE 240 VLQQDKTSSN 250 LHEAASDCVC 260 SALYAIENVE 270 TNLPLAMQLF 280 QGVLTLETAY 290 HMAVAREDLD 300 KVLNYCRIFT 310 ELCETFLEKI 320 VCTPGQGLGD 330 LRTLELLLIC 340 AGHPQYEVVE 350 ISFNFWYRLG 360 EHLYKTNDEV 370 IHGIFKAYIQ 380 RLLHALARHC 390 QLEPDHEGVP 400 EETDDFGEFR 410 MRVSDLVKDL 420 IFLIGSMECF 430 AQLYSTLKEG 440 NPPWEVTEAV 450 LFIMAAIAKS 460 VDPENNPTLV 470 EVLEGVVRLP 480 ETVHTAVRYT 490 SIELVGEMSE 500 VVDRNPQFLD 510 PVLGYLMKGL 520 CEKPLASAAA 530 KAIHNICSVC 540 RDHMAQHFNG 550 LLEIARSLDS 560 FLLSPEAAVG 570 LLKGTALVLA 580 RLPLDKITEC 590 LSELCSVQVM 600 ALKKLLSQEP 610 SNGISSDPTV 620 FLDRLAVIFR 630 HTNPIVENGQ 640 THPCQKVIQE 650 IWPVLSETLN 660 KHRADNRIVE 670 RCCRCLRFAV 680 RCVGKGSAAL 690 LQPLVTQMVN 700 VYHVHQHSCF 710 LYLGSILVDE 720 YGMEEGCRQG 730 LLDMLQALCI 740 PTFQLLEQQN 750 GLQNHPDTVD 760 DLFRLATRFI 770 QRSPVTLLRS 780 QVVIPILQWA 790 IASTTLDHRD 800 ANCSVMRFLR 810 DLIHTGVAND 820 HEEDFELRKE 830 LIGQVMNQLG 840 QQLVSQLLHT 850 CCFCLPPYTL 860 PDVAEVLWEI 870 MQVDRPTFCR 880 WLENSLKGLP 890 KETTVGAVTV 900 THKQLTDFHK 910 QVTSAEECKQ 920 VCWALRDFTR LFR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005642 annulate lamellae
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0061608 nuclear import signal receptor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006606 protein import into nucleus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.