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Overview

Uniprot ID	Q9Y5N6
Protein Name	Origin recognition complex subunit 6
Gene Name	ORC6
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
202	TPPRKRKKIVVEAPA
238	DYEEWKRKILENAAS

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3

Protein Sequence

10 MGSELIGRLA 20 PRLGLAEPDM 30 LRKAEEYLRL 40 SRVKCVGLSA 50 RTTETSSAVM 60 CLDLAASWMK 70 CPLDRAYLIK 80 LSGLNKETYQ 90 SCLKSFECLL 100 GLNSNIGIRD 110 LAVQFSCIEA 120 VNMASKILKS 130 YESSLPQTQQ 140 VDLDLSRPLF 150 TSAALLSACK 160 ILKLKVDKNK 170 MVATSGVKKA 180 IFDRLCKQLE 190 KIGQQVDREP 200 GDVATPPRKR 210 KKIVVEAPAK 220 EMEKVEEMPH 230 KPQKDEDLTQ 240 DYEEWKRKIL 250 ENAASAQKAT AE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0001650	fibrillar center
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005664	nuclear origin of replication recognition complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000808	origin recognition complex
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006270	DNA replication initiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.