Search Results
Overview
| Uniprot ID | Q9Y5P6 |
|---|---|
| Protein Name | Mannose-1-phosphate guanylyltransferase catalytic subunit beta |
| Gene Name | GMPPB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 143 | TKVEEPSKYGVVVCE |
Function
Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex (PubMed:33986552). Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids (PubMed:33986552). Can catalyze the reverse reaction in vitro (PubMed:33986552). Together with GMPPA regulates GDP-alpha-D-mannose levels (PubMed:33986552)
Protein Sequence
10
MKALILVGGY
20
GTRLRPLTLS
30
TPKPLVDFCN
40
KPILLHQVEA
50
LAAAGVDHVI
60
LAVSYMSQVL
70
EKEMKAQEQR
80
LGIRISMSHE
90
EEPLGTAGPL
100
ALARDLLSET
110
ADPFFVLNSD
120
VICDFPFQAM
130
VQFHRHHGQE
140
GSILVTKVEE
150
PSKYGVVVCE
160
ADTGRIHRFV
170
EKPQVFVSNK
180
INAGMYILSP
190
AVLQRIQLQP
200
TSIEKEVFPI
210
MAKEGQLYAM
220
ELQGFWMDIG
230
QPKDFLTGMC
240
LFLQSLRQKQ
250
PERLCSGPGI
260
VGNVLVDPSA
270
RIGQNCSIGP
280
NVSLGPGVVV
290
EDGVCIRRCT
300
VLRDARIRSH
310
SWLESCIVGW
320
RCRVGQWVRM
330
ENVTVLGEDV
340
IVNDELYLNG
350
ASVLPHKSIG
360
ESVPEPRIIM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0120508 | GDP-mannose pyrophosphorylase complex |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0004475 | mannose-1-phosphate guanylyltransferase (GTP) activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0009298 | GDP-mannose biosynthetic process |
| Biological Process | GO:0019673 | GDP-mannose metabolic process |
Reference
PMID: N/A