Overview
| Uniprot ID | Q9Y5Q3 |
|---|
| Protein Name | Transcription factor MafB |
|---|
| Gene Name | MAFB |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 281 |
IQQVEQLKQEVSRLA |
Function
Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity)
Protein Sequence
10
MAAELSMGPE
20
LPTSPLAMEY
30
VNDFDLLKFD
40
VKKEPLGRAE
50
RPGRPCTRLQ
60
PAGSVSSTPL
70
STPCSSVPSS
80
PSFSPTEQKT
90
HLEDLYWMAS
100
NYQQMNPEAL
110
NLTPEDAVEA
120
LIGSHPVPQP
130
LQSFDSFRGA
140
HHHHHHHHPH
150
PHHAYPGAGV
160
AHDELGPHAH
170
PHHHHHHQAS
180
PPPSSAASPA
190
QQLPTSHPGP
200
GPHATASATA
210
AGGNGSVEDR
220
FSDDQLVSMS
230
VRELNRHLRG
240
FTKDEVIRLK
250
QKRRTLKNRG
260
YAQSCRYKRV
270
QQKHHLENEK
280
TQLIQQVEQL
290
KQEVSRLARE
300
RDAYKVKCEK
310
LANSGFREAG
320
STSDSPSSPE
FFL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005667 |
transcription regulator complex |
| Molecular Function |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0043565 |
sequence-specific DNA binding |
| Biological Process |
GO:0021599 |
abducens nerve formation |
| Biological Process |
GO:1903575 |
cornified envelope assembly |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045444 |
fat cell differentiation |
| Biological Process |
GO:0140467 |
integrated stress response signaling |
| Biological Process |
GO:0030216 |
keratinocyte differentiation |
| Biological Process |
GO:0045647 |
negative regulation of erythrocyte differentiation |
| Biological Process |
GO:0045671 |
negative regulation of osteoclast differentiation |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0016485 |
protein processing |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0045637 |
regulation of myeloid cell differentiation |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0007423 |
sensory organ development |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.