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Overview

Uniprot ID	Q9Y5Q9
Protein Name	General transcription factor 3C polypeptide 3
Gene Name	GTF3C3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
508	QQLGQPEKALEALEP

Function

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

Protein Sequence

10 MSGFSPELID 20 YLEGKISFEE 30 FERRREERKT 40 REKKSLQEKG 50 KLSAEENPDD 60 SEVPSSSGIN 70 STKSQDKDVN 80 EGETSDGVRK 90 SVHKVFASML 100 GENEDDEEEE 110 EEEEEEEEEE 120 ETPEQPTAGD 130 VFVLEMVLNR 140 ETKKMMKEKR 150 PRSKLPRALR 160 GLMGEANIRF 170 ARGEREEAIL 180 MCMEIIRQAP 190 LAYEPFSTLA 200 MIYEDQGDME 210 KSLQFELIAA 220 HLNPSDTEEW 230 VRLAEMSLEQ 240 DNIKQAIFCY 250 TKALKYEPTN 260 VRYLWERSSL 270 YEQMGDHKMA 280 MDGYRRILNL 290 LSPSDGERFM 300 QLARDMAKSY 310 YEANDVTSAI 320 NIIDEAFSKH 330 QGLVSMEDVN 340 IAAELYISNK 350 QYDKALEIIT 360 DFSGIVLEKK 370 TSEEGTSEEN 380 KAPENVTCTI 390 PDGVPIDITV 400 KLMVCLVHLN 410 ILEPLNPLLT 420 TLVEQNPEDM 430 GDLYLDVAEA 440 FLDVGEYNSA 450 LPLLSALVCS 460 ERYNLAVVWL 470 RHAECLKALG 480 YMERAAESYG 490 KVVDLAPLHL 500 DARISLSTLQ 510 QQLGQPEKAL 520 EALEPMYDPD 530 TLAQDANAAQ 540 QELKLLLHRS 550 TLLFSQGKMY 560 GYVDTLLTML 570 AMLLKVAMNR 580 AQVCLISSSK 590 SGERHLYLIK 600 VSRDKISDSN 610 DQESANCDAK 620 AIFAVLTSVL 630 TKDDWWNLLL 640 KAIYSLCDLS 650 RFQEAELLVD 660 SSLEYYSFYD 670 DRQKRKELEY 680 FGLSAAILDK 690 NFRKAYNYIR 700 IMVMENVNKP 710 QLWNIFNQVT 720 MHSQDVRHHR 730 FCLRLMLKNP 740 ENHALCVLNG 750 HNAFVSGSFK 760 HALGQYVQAF 770 RTHPDEPLYS 780 FCIGLTFIHM 790 ASQKYVLRRH 800 ALIVQGFSFL 810 NRYLSLRGPC 820 QESFYNLGRG 830 LHQLGLIHLA 840 IHYYQKALEL 850 PPLVVEGIEL 860 DQLDLRRDIA 870 YNLSLIYQSS 880 GNTGMAQTLL YTYCSI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0001650	fibrillar center
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000127	transcription factor TFIIIC complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0000995	RNA polymerase III general transcription initiation factor activity
Biological Process	GO:0042791	5S class rRNA transcription by RNA polymerase III
Biological Process	GO:0006383	transcription by RNA polymerase III
Biological Process	GO:0006384	transcription initiation at RNA polymerase III promoter
Biological Process	GO:0042797	tRNA transcription by RNA polymerase III

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.