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Overview

Uniprot ID	Q9Y5S2
Protein Name	Serine/threonine-protein kinase MRCK beta
Gene Name	CDC42BPB
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
426	MQSNTLTKDEDVQRD

Function

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity)

Protein Sequence

10 MSAKVRLKKL 20 EQLLLDGPWR 30 NESALSVETL 40 LDVLVCLYTE 50 CSHSALRRDK 60 YVAEFLEWAK 70 PFTQLVKEMQ 80 LHREDFEIIK 90 VIGRGAFGEV 100 AVVKMKNTER 110 IYAMKILNKW 120 EMLKRAETAC 130 FREERDVLVN 140 GDCQWITALH 150 YAFQDENHLY 160 LVMDYYVGGD 170 LLTLLSKFED 180 KLPEDMARFY 190 IGEMVLAIDS 200 IHQLHYVHRD 210 IKPDNVLLDV 220 NGHIRLADFG 230 SCLKMNDDGT 240 VQSSVAVGTP 250 DYISPEILQA 260 MEDGMGKYGP 270 ECDWWSLGVC 280 MYEMLYGETP 290 FYAESLVETY 300 GKIMNHEERF 310 QFPSHVTDVS 320 EEAKDLIQRL 330 ICSRERRLGQ 340 NGIEDFKKHA 350 FFEGLNWENI 360 RNLEAPYIPD 370 VSSPSDTSNF 380 DVDDDVLRNT 390 EILPPGSHTG 400 FSGLHLPFIG 410 FTFTTESCFS 420 DRGSLKSIMQ 430 SNTLTKDEDV 440 QRDLEHSLQM 450 EAYERRIRRL 460 EQEKLELSRK 470 LQESTQTVQS 480 LHGSSRALSN 490 SNRDKEIKKL 500 NEEIERLKNK 510 IADSNRLERQ 520 LEDTVALRQE 530 REDSTQRLRG 540 LEKQHRVVRQ 550 EKEELHKQLV 560 EASERLKSQA 570 KELKDAHQQR 580 KLALQEFSEL 590 NERMAELRAQ 600 KQKVSRQLRD 610 KEEEMEVATQ 620 KVDAMRQEMR 630 RAEKLRKELE 640 AQLDDAVAEA 650 SKERKLREHS 660 ENFCKQMESE 670 LEALKVKQGG 680 RGAGATLEHQ 690 QEISKIKSEL 700 EKKVLFYEEE 710 LVRREASHVL 720 EVKNVKKEVH 730 DSESHQLALQ 740 KEILMLKDKL 750 EKSKRERHNE 760 MEEAVGTIKD 770 KYERERAMLF 780 DENKKLTAEN 790 EKLCSFVDKL 800 TAQNRQLEDE 810 LQDLAAKKES 820 VAHWEAQIAE 830 IIQWVSDEKD 840 ARGYLQALAS 850 KMTEELEALR 860 SSSLGSRTLD 870 PLWKVRRSQK 880 LDMSARLELQ 890 SALEAEIRAK 900 QLVQEELRKV 910 KDANLTLESK 920 LKDSEAKNRE 930 LLEEMEILKK 940 KMEEKFRADT 950 GLKLPDFQDS 960 IFEYFNTAPL 970 AHDLTFRTSS 980 ASEQETQAPK 990 PEASPSMSVA 1000 ASEQQEDMAR 1010 PPQRPSAVPL 1020 PTTQALALAG 1030 PKPKAHQFSI 1040 KSFSSPTQCS 1050 HCTSLMVGLI 1060 RQGYACEVCS 1070 FACHVSCKDG 1080 APQVCPIPPE 1090 QSKRPLGVDV 1100 QRGIGTAYKG 1110 HVKVPKPTGV 1120 KKGWQRAYAV 1130 VCDCKLFLYD 1140 LPEGKSTQPG 1150 VIASQVLDLR 1160 DDEFSVSSVL 1170 ASDVIHATRR 1180 DIPCIFRVTA 1190 SLLGAPSKTS 1200 SLLILTENEN 1210 EKRKWVGILE 1220 GLQSILHKNR 1230 LRNQVVHVPL 1240 EAYDSSLPLI 1250 KAILTAAIVD 1260 ADRIAVGLEE 1270 GLYVIEVTRD 1280 VIVRAADCKK 1290 VHQIELAPRE 1300 KIVILLCGRN 1310 HHVHLYPWSS 1320 LDGAEGSFDI 1330 KLPETKGCQL 1340 MATATLKRNS 1350 GTCLFVAVKR 1360 LILCYEIQRT 1370 KPFHRKFNEI 1380 VAPGSVQCLA 1390 VLRDRLCVGY 1400 PSGFCLLSIQ 1410 GDGQPLNLVN 1420 PNDPSLAFLS 1430 QQSFDALCAV 1440 ELESEEYLLC 1450 FSHMGLYVDP 1460 QGRRARAQEL 1470 MWPAAPVACS 1480 CSPTHVTVYS 1490 EYGVDVFDVR 1500 TMEWVQTIGL 1510 RRIRPLNSEG 1520 TLNLLNCEPP 1530 RLIYFKSKFS 1540 GAVLNVPDTS 1550 DNSKKQMLRT 1560 RSKRRFVFKV 1570 PEEERLQQRR 1580 EMLRDPELRS 1590 KMISNPTNFN 1600 HVAHMGPGDG 1610 MQVLMDLPLS 1620 AVPPSQEERP 1630 GPAPTNLARQ 1640 PPSRNKPYIS 1650 WPSSGGSEPS 1660 VTVPLRSMSD 1670 PDQDFDKEPD 1680 SDSTKHSTPS 1690 NSSNPSGPPS 1700 PNSPHRSQLP 1710 LEGLEQPACD T

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0031252	cell leading edge
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0000287	magnesium ion binding
Molecular Function	GO:0004672	protein kinase activity
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0016477	cell migration
Biological Process	GO:0007010	cytoskeleton organization
Biological Process	GO:0007163	establishment or maintenance of cell polarity
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0007165	signal transduction

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.