Search Results
Overview
| Uniprot ID | Q9Y5U8 |
|---|---|
| Protein Name | Mitochondrial pyruvate carrier 1 |
| Gene Name | MPC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | IQGGRLIKHEMTKTA |
| 46 | AAINDMKKSPEIISG |
| 8 | MAGALVRKAADYVRS |
Function
Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (PubMed:22628558, PubMed:26253029, PubMed:27317664, PubMed:40044865, PubMed:40101766). Plays an essential role in cellular metabolism (PubMed:40044865, PubMed:40101766)
Protein Sequence
10
MAGALVRKAA
20
DYVRSKDFRD
30
YLMSTHFWGP
40
VANWGLPIAA
50
INDMKKSPEI
60
ISGRMTFALC
70
CYSLTFMRFA
80
YKVQPRNWLL
90
FACHATNEVA
100
QLIQGGRLIK
HEMTKTASA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0050833 | pyruvate transmembrane transporter activity |
| Biological Process | GO:0006850 | pyruvate import into mitochondria |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.