Search Results
Overview
| Uniprot ID | Q9Y5V0 |
|---|---|
| Protein Name | Transcriptional regulator ZNF706 |
| Gene Name | ZNF706 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | QKIQSQQKNAKKQAG |
| 7 | *MARGQQKIQSQQKN |
Function
Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal (By similarity). Acts by repressing expression of KLF4 (By similarity). Required for Wnt signaling activation (PubMed:41298547)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:1902455 | negative regulation of stem cell population maintenance |
| Biological Process | GO:0006417 | regulation of translation |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.