Search Results

Overview

Uniprot IDQ9Y5V3
Protein NameMelanoma-associated antigen D1
Gene NameMAGED1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
182 SRPKTPFKAWNDTTK
251 IRGKRTRKINNLNVE
79 ARPKSAFKVQNATTK

Function

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed

Protein Sequence

10 MAQKMDCGAG 20 LLGFQAEASV 30 EDSALLMQTL 40 MEAIQISEAP 50 PTNQATAAAS 60 PQSSQPPTAN 70 EMADIQVSAA 80 AARPKSAFKV 90 QNATTKGPNG 100 VYDFSQAHNA 110 KDVPNTQPKA 120 AFKSQNATPK 130 GPNAAYDFSQ 140 AATTGELAAN 150 KSEMAFKAQN 160 ATTKVGPNAT 170 YNFSQSLNAN 180 DLANSRPKTP 190 FKAWNDTTKA 200 PTADTQTQNV 210 NQAKMATSQA 220 DIETDPGISE 230 PDGATAQTSA 240 DGSQAQNLES 250 RTIIRGKRTR 260 KINNLNVEEN 270 SSGDQRRAPL 280 AAGTWRSAPV 290 PVTTQNPPGA 300 PPNVLWQTPL 310 AWQNPSGWQN 320 QTARQTPPAR 330 QSPPARQTPP 340 AWQNPVAWQN 350 PVIWPNPVIW 360 QNPVIWPNPI 370 VWPGPVVWPN 380 PLAWQNPPGW 390 QTPPGWQTPP 400 GWQGPPDWQG 410 PPDWPLPPDW 420 PLPPDWPLPT 430 DWPLPPDWIP 440 ADWPIPPDWQ 450 NLRPSPNLRP 460 SPNSRASQNP 470 GAAQPRDVAL 480 LQERANKLVK 490 YLMLKDYTKV 500 PIKRSEMLRD 510 IIREYTDVYP 520 EIIERACFVL 530 EKKFGIQLKE 540 IDKEEHLYIL 550 ISTPESLAGI 560 LGTTKDTPKL 570 GLLLVILGVI 580 FMNGNRASEA 590 VLWEALRKMG 600 LRPGVRHPLL 610 GDLRKLLTYE 620 FVKQKYLDYR 630 RVPNSNPPEY 640 EFLWGLRSYH 650 ETSKMKVLRF 660 IAEVQKRDPR 670 DWTAQFMEAA 680 DEALDALDAA 690 AAEAEARAEA 700 RTRMGIGDEA 710 VSGPWSWDDI 720 EFELLTWDEE 730 GDFGDPWSRI 740 PFTFWARYHQ 750 NARSRFPQTF 760 AGPIIGPGGT 770 ASANFAANFG AIGFFWVE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.