Search Results

Overview

Uniprot IDQ9Y5X1
Protein NameSorting nexin-9
Gene NameSNX9
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
179 PKSSSYFKDSESADA
202 RASSSSMKIPLNKFP
207 SMKIPLNKFPGFAKP
262 ADPRKGSKMYGLKSY
425 TVGQEHWKRCTGPLP

Function

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate

Protein Sequence

10 MATKARVMYD 20 FAAEPGNNEL 30 TVNEGEIITI 40 TNPDVGGGWL 50 EGRNIKGERG 60 LVPTDYVEIL 70 PSDGKDQFSC 80 GNSVADQAFL 90 DSLSASTAQA 100 SSSAASNNHQ 110 VGSGNDPWSA 120 WSASKSGNWE 130 SSEGWGAQPE 140 GAGAQRNTNT 150 PNNWDTAFGH 160 PQAYQGPATG 170 DDDDWDEDWD 180 GPKSSSYFKD 190 SESADAGGAQ 200 RGNSRASSSS 210 MKIPLNKFPG 220 FAKPGTEQYL 230 LAKQLAKPKE 240 KIPIIVGDYG 250 PMWVYPTSTF 260 DCVVADPRKG 270 SKMYGLKSYI 280 EYQLTPTNTN 290 RSVNHRYKHF 300 DWLYERLLVK 310 FGSAIPIPSL 320 PDKQVTGRFE 330 EEFIKMRMER 340 LQAWMTRMCR 350 HPVISESEVF 360 QQFLNFRDEK 370 EWKTGKRKAE 380 RDELAGVMIF 390 STMEPEAPDL 400 DLVEIEQKCE 410 AVGKFTKAMD 420 DGVKELLTVG 430 QEHWKRCTGP 440 LPKEYQKIGK 450 ALQSLATVFS 460 SSGYQGETDL 470 NDAITEAGKT 480 YEEIASLVAE 490 QPKKDLHFLM 500 ECNHEYKGFL 510 GCFPDIIGTH 520 KGAIEKVKES 530 DKLVATSKIT 540 LQDKQNMVKR 550 VSIMSYALQA 560 EMNHFHSNRI 570 YDYNSVIRLY 580 LEQQVQFYET 590 IAEKLRQALS RFPVM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0032437 cuticular plate
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0030659 cytoplasmic vesicle membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001726 ruffle
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0005545 1-phosphatidylinositol binding
Molecular Function GO:0071933 Arp2/3 complex binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0036089 cleavage furrow formation
Biological Process GO:0006897 endocytosis
Biological Process GO:0016197 endosomal transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0060988 lipid tube assembly
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0097320 plasma membrane tubulation
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0006898 receptor-mediated endocytosis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.