Overview
| Uniprot ID | Q9Y5X3 |
|---|
| Protein Name | Sorting nexin-5 |
|---|
| Gene Name | SNX5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 138 |
EYLAVFKKTVSSHEV |
Function
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941)
Protein Sequence
10
MAAVPELLQQ
20
QEEDRSKLRS
30
VSVDLNVDPS
40
LQIDIPDALS
50
ERDKVKFTVH
60
TKTTLPTFQS
70
PEFSVTRQHE
80
DFVWLHDTLI
90
ETTDYAGLII
100
PPAPTKPDFD
110
GPREKMQKLG
120
EGEGSMTKEE
130
FAKMKQELEA
140
EYLAVFKKTV
150
SSHEVFLQRL
160
SSHPVLSKDR
170
NFHVFLEYDQ
180
DLSVRRKNTK
190
EMFGGFFKSV
200
VKSADEVLFT
210
GVKEVDDFFE
220
QEKNFLINYY
230
NRIKDSCVKA
240
DKMTRSHKNV
250
ADDYIHTAAC
260
LHSLALEEPT
270
VIKKYLLKVA
280
ELFEKLRKVE
290
GRVSSDEDLK
300
LTELLRYYML
310
NIEAAKDLLY
320
RRTKALIDYE
330
NSNKALDKAR
340
LKSKDVKLAE
350
AHQQECCQKF
360
EQLSESAKEE
370
LINFKRKRVA
380
AFRKNLIEMS
390
ELEIKHARNN
400
VSLLQSCIDL
FKNN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005903 |
brush border |
| Cellular Component |
GO:0098559 |
cytoplasmic side of early endosome membrane |
| Cellular Component |
GO:0009898 |
cytoplasmic side of plasma membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0070685 |
macropinocytic cup |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0001891 |
phagocytic cup |
| Cellular Component |
GO:0030904 |
retromer complex |
| Cellular Component |
GO:0030905 |
retromer, tubulation complex |
| Cellular Component |
GO:0001726 |
ruffle |
| Cellular Component |
GO:0097422 |
tubular endosome |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0031748 |
D1 dopamine receptor binding |
| Molecular Function |
GO:0034452 |
dynactin binding |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Molecular Function |
GO:0080025 |
phosphatidylinositol-3,5-bisphosphate binding |
| Molecular Function |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
| Molecular Function |
GO:0010314 |
phosphatidylinositol-5-phosphate binding |
| Biological Process |
GO:0097750 |
endosome membrane tubulation |
| Biological Process |
GO:0007174 |
epidermal growth factor catabolic process |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0045776 |
negative regulation of blood pressure |
| Biological Process |
GO:0006907 |
pinocytosis |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0046628 |
positive regulation of insulin receptor signaling pathway |
| Biological Process |
GO:0016241 |
regulation of macroautophagy |
| Biological Process |
GO:0042147 |
retrograde transport, endosome to Golgi |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.