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Overview

Uniprot IDQ9Y613
Protein NameFH1/FH2 domain-containing protein 1
Gene NameFHOD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1143 KSLRRTLKSGLGDDL

Function

Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing

Protein Sequence

10 MAGGEDRGDG 20 EPVSVVTVRV 30 QYLEDTDPFA 40 CANFPEPRRA 50 PTCSLDGALP 60 LGAQIPAVHR 70 LLGAPLKLED 80 CALQVSPSGY 90 YLDTELSLEE 100 QREMLEGFYE 110 EISKGRKPTL 120 ILRTQLSVRV 130 NAILEKLYSS 140 SGPELRRSLF 150 SLKQIFQEDK 160 DLVPEFVHSE 170 GLSCLIRVGA 180 AADHNYQSYI 190 LRALGQLMLF 200 VDGMLGVVAH 210 SDTIQWLYTL 220 CASLSRLVVK 230 TALKLLLVFV 240 EYSENNAPLF 250 IRAVNSVAST 260 TGAPPWANLV 270 SILEEKNGAD 280 PELLVYTVTL 290 INKTLAALPD 300 QDSFYDVTDA 310 LEQQGMEALV 320 QRHLGTAGTD 330 VDLRTQLVLY 340 ENALKLEDGD 350 IEEAPGAGGR 360 RERRKPSSEE 370 GKRSRRSLEG 380 GGCPARAPEP 390 GPTGPASPVG 400 PTSSTGPALL 410 TGPASSPVGP 420 PSGLQASVNL 430 FPTISVAPSA 440 DTSSERSIYK 450 ARFLENVAAA 460 ETEKQVALAQ 470 GRAETLAGAM 480 PNEAGGHPDA 490 RQLWDSPETA 500 PAARTPQSPA 510 PCVLLRAQRS 520 LAPEPKEPLI 530 PASPKAEPIW 540 ELPTRAPRLS 550 IGDLDFSDLG 560 EDEDQDMLNV 570 ESVEAGKDIP 580 APSPPLPLLS 590 GVPPPPPLPP 600 PPPIKGPFPP 610 PPPLPLAAPL 620 PHSVPDSSAL 630 PTKRKTVKLF 640 WRELKLAGGH 650 GVSASRFGPC 660 ATLWASLDPV 670 SVDTARLEHL 680 FESRAKEVLP 690 SKKAGEGRRT 700 MTTVLDPKRS 710 NAINIGLTTL 720 PPVHVIKAAL 730 LNFDEFAVSK 740 DGIEKLLTMM 750 PTEEERQKIE 760 EAQLANPDIP 770 LGPAENFLMT 780 LASIGGLAAR 790 LQLWAFKLDY 800 DSMEREIAEP 810 LFDLKVGMEQ 820 LVQNATFRCI 830 LATLLAVGNF 840 LNGSQSSGFE 850 LSYLEKVSEV 860 KDTVRRQSLL 870 HHLCSLVLQT 880 RPESSDLYSE 890 IPALTRCAKV 900 DFEQLTENLG 910 QLERRSRAAE 920 ESLRSLAKHE 930 LAPALRARLT 940 HFLDQCARRV 950 AMLRIVHRRV 960 CNRFHAFLLY 970 LGYTPQAARE 980 VRIMQFCHTL 990 REFALEYRTC 1000 RERVLQQQQK 1010 QATYRERNKT 1020 RGRMITETEK 1030 FSGVAGEAPS 1040 NPSVPVAVSS 1050 GPGRGDADSH 1060 ASMKSLLTSR 1070 PEDTTHNRRS 1080 RGMVQSSSPI 1090 MPTVGPSTAS 1100 PEEPPGSSLP 1110 SDTSDEIMDL 1120 LVQSVTKSSP 1130 RALAARERKR 1140 SRGNRKSLRR 1150 TLKSGLGDDL 1160 VQALGLSKGP GLEV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0032059 bleb
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0014704 intercalated disc
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0051015 actin filament binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0051496 positive regulation of stress fiber assembly
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0051492 regulation of stress fiber assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.