Search Results

Overview

Uniprot IDQ9Y618
Protein NameNuclear receptor corepressor 2
Gene NameNCOR2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 EMEFIESKRPRLELL
1064 VPPREVIKASPHAPD
1160 PLPMDPKKLAPFSGV
1210 VPGGSITKGIPSTRV
1240 TPADVLYKGTITRII
1265 GREDSLPKGHVIYEG
1273 GHVIYEGKKGHVLSY
1291 MSVTQCSKEDGRSSS
1308 PHETAAPKRTYDMME
1398 RDLTEAYKTQALGPL
1406 TQALGPLKLKPAHEG
1419 EGLVATVKEAGRSIH
1447 PLAPRPLKEGSITQG
1458 ITQGTPLKYDTGAST
1469 GASTTGSKKHDVRSL
1470 ASTTGSKKHDVRSLI
1509 ACYEESLKSRPGTAS
1535 VIVPELGKPRQSPLT
1578 EGSLSSSKASQDRKL
1584 SKASQDRKLTSTPRE
1594 STPREIAKSPHSTVP
192 MVEQQISKLKKKQQQ
194 EQQISKLKKKQQQLE
1974 EPASSPSKGSEPRPL
1997 TIARTPAKNLAPHHA
2022 ASDPHREKTQSKPFS
2086 LEGELRPKQPGPVKL
2271 QPPAFFSKLTESNSA
2281 ESNSAMVKSKKQEIN
2283 NSAMVKSKKQEINKK
2399 TSPGGGGKAKVSGRP
279 INQAMRKKLILYFKR
335 KVREYYEKQFPEIRK
547 NDKEDLLKEKTDDTS
625 EEMETAKKGLLEHGR
650 SKTVSQCKNFYFNYK
657 KNFYFNYKKRQNLDE
658 NFYFNYKKRQNLDEI
670 DEILQQHKLKMEKER
672 ILQQHKLKMEKERNA
878 EEGPAKGKDAEAAEA
892 ATAEGALKAEKKEGG
895 EGALKAEKKEGGSGR
964 PQKPLDLKQLKQRAA

Function

Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription (PubMed:10077563, PubMed:10097068, PubMed:18212045, PubMed:20812024, PubMed:22230954, PubMed:23911289). Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3 (PubMed:22230954). Required to activate the histone deacetylase activity of HDAC3 (PubMed:22230954). Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival (PubMed:18212045, PubMed:23911289). Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024)

Protein Sequence

10 MSGSTQPVAQ 20 TWRATEPRYP 30 PHSLSYPVQI 40 ARTHTDVGLL 50 EYQHHSRDYA 60 SHLSPGSIIQ 70 PQRRRPSLLS 80 EFQPGNERSQ 90 ELHLRPESHS 100 YLPELGKSEM 110 EFIESKRPRL 120 ELLPDPLLRP 130 SPLLATGQPA 140 GSEDLTKDRS 150 LTGKLEPVSP 160 PSPPHTDPEL 170 ELVPPRLSKE 180 ELIQNMDRVD 190 REITMVEQQI 200 SKLKKKQQQL 210 EEEAAKPPEP 220 EKPVSPPPIE 230 SKHRSLVQII 240 YDENRKKAEA 250 AHRILEGLGP 260 QVELPLYNQP 270 SDTRQYHENI 280 KINQAMRKKL 290 ILYFKRRNHA 300 RKQWEQKFCQ 310 RYDQLMEAWE 320 KKVERIENNP 330 RRRAKESKVR 340 EYYEKQFPEI 350 RKQRELQERM 360 QSRVGQRGSG 370 LSMSAARSEH 380 EVSEIIDGLS 390 EQENLEKQMR 400 QLAVIPPMLY 410 DADQQRIKFI 420 NMNGLMADPM 430 KVYKDRQVMN 440 MWSEQEKETF 450 REKFMQHPKN 460 FGLIASFLER 470 KTVAECVLYY 480 YLTKKNENYK 490 SLVRRSYRRR 500 GKSQQQQQQQ 510 QQQQQQQQQQ 520 PMPRSSQEEK 530 DEKEKEKEAE 540 KEEEKPEVEN 550 DKEDLLKEKT 560 DDTSGEDNDE 570 KEAVASKGRK 580 TANSQGRRKG 590 RITRSMANEA 600 NSEEAITPQQ 610 SAELASMELN 620 ESSRWTEEEM 630 ETAKKGLLEH 640 GRNWSAIARM 650 VGSKTVSQCK 660 NFYFNYKKRQ 670 NLDEILQQHK 680 LKMEKERNAR 690 RKKKKAPAAA 700 SEEAAFPPVV 710 EDEEMEASGV 720 SGNEEEMVEE 730 AEALHASGNE 740 VPRGECSGPA 750 TVNNSSDTES 760 IPSPHTEAAK 770 DTGQNGPKPP 780 ATLGADGPPP 790 GPPTPPPEDI 800 PAPTEPTPAS 810 EATGAPTPPP 820 APPSPSAPPP 830 VVPKEEKEEE 840 TAAAPPVEEG 850 EEQKPPAAEE 860 LAVDTGKAEE 870 PVKSECTEEA 880 EEGPAKGKDA 890 EAAEATAEGA 900 LKAEKKEGGS 910 GRATTAKSSG 920 APQDSDSSAT 930 CSADEVDEAE 940 GGDKNRLLSP 950 RPSLLTPTGD 960 PRANASPQKP 970 LDLKQLKQRA 980 AAIPPIQVTK 990 VHEPPREDAA 1000 PTKPAPPAPP 1010 PPQNLQPESD 1020 APQQPGSSPR 1030 GKSRSPAPPA 1040 DKEAFAAEAQ 1050 KLPGDPPCWT 1060 SGLPFPVPPR 1070 EVIKASPHAP 1080 DPSAFSYAPP 1090 GHPLPLGLHD 1100 TARPVLPRPP 1110 TISNPPPLIS 1120 SAKHPSVLER 1130 QIGAISQGMS 1140 VQLHVPYSEH 1150 AKAPVGPVTM 1160 GLPLPMDPKK 1170 LAPFSGVKQE 1180 QLSPRGQAGP 1190 PESLGVPTAQ 1200 EASVLRGTAL 1210 GSVPGGSITK 1220 GIPSTRVPSD 1230 SAITYRGSIT 1240 HGTPADVLYK 1250 GTITRIIGED 1260 SPSRLDRGRE 1270 DSLPKGHVIY 1280 EGKKGHVLSY 1290 EGGMSVTQCS 1300 KEDGRSSSGP 1310 PHETAAPKRT 1320 YDMMEGRVGR 1330 AISSASIEGL 1340 MGRAIPPERH 1350 SPHHLKEQHH 1360 IRGSITQGIP 1370 RSYVEAQEDY 1380 LRREAKLLKR 1390 EGTPPPPPPS 1400 RDLTEAYKTQ 1410 ALGPLKLKPA 1420 HEGLVATVKE 1430 AGRSIHEIPR 1440 EELRHTPELP 1450 LAPRPLKEGS 1460 ITQGTPLKYD 1470 TGASTTGSKK 1480 HDVRSLIGSP 1490 GRTFPPVHPL 1500 DVMADARALE 1510 RACYEESLKS 1520 RPGTASSSGG 1530 SIARGAPVIV 1540 PELGKPRQSP 1550 LTYEDHGAPF 1560 AGHLPRGSPV 1570 TTREPTPRLQ 1580 EGSLSSSKAS 1590 QDRKLTSTPR 1600 EIAKSPHSTV 1610 PEHHPHPISP 1620 YEHLLRGVSG 1630 VDLYRSHIPL 1640 AFDPTSIPRG 1650 IPLDAAAAYY 1660 LPRHLAPNPT 1670 YPHLYPPYLI 1680 RGYPDTAALE 1690 NRQTIINDYI 1700 TSQQMHHNAA 1710 TAMAQRADML 1720 RGLSPRESSL 1730 ALNYAAGPRG 1740 IIDLSQVPHL 1750 PVLVPPTPGT 1760 PATAMDRLAY 1770 LPTAPQPFSS 1780 RHSSSPLSPG 1790 GPTHLTKPTT 1800 TSSSERERDR 1810 DRERDRDRER 1820 EKSILTSTTT 1830 VEHAPIWRPG 1840 TEQSSGSSGG 1850 GGGSSSRPAS 1860 HSHAHQHSPI 1870 SPRTQDALQQ 1880 RPSVLHNTGM 1890 KGIITAVEPS 1900 TPTVLRSTST 1910 SSPVRPAATF 1920 PPATHCPLGG 1930 TLDGVYPTLM 1940 EPVLLPKEAP 1950 RVARPERPRA 1960 DTGHAFLAKP 1970 PARSGLEPAS 1980 SPSKGSEPRP 1990 LVPPVSGHAT 2000 IARTPAKNLA 2010 PHHASPDPPA 2020 PPASASDPHR 2030 EKTQSKPFSI 2040 QELELRSLGY 2050 HGSSYSPEGV 2060 EPVSPVSSPS 2070 LTHDKGLPKH 2080 LEELDKSHLE 2090 GELRPKQPGP 2100 VKLGGEAAHL 2110 PHLRPLPESQ 2120 PSSSPLLQTA 2130 PGVKGHQRVV 2140 TLAQHISEVI 2150 TQDYTRHHPQ 2160 QLSAPLPAPL 2170 YSFPGASCPV 2180 LDLRRPPSDL 2190 YLPPPDHGAP 2200 ARGSPHSEGG 2210 KRSPEPNKTS 2220 VLGGGEDGIE 2230 PVSPPEGMTE 2240 PGHSRSAVYP 2250 LLYRDGEQTE 2260 PSRMGSKSPG 2270 NTSQPPAFFS 2280 KLTESNSAMV 2290 KSKKQEINKK 2300 LNTHNRNEPE 2310 YNISQPGTEI 2320 FNMPAITGTG 2330 LMTYRSQAVQ 2340 EHASTNMGLE 2350 AIIRKALMGK 2360 YDQWEESPPL 2370 SANAFNPLNA 2380 SASLPAAMPI 2390 TAADGRSDHT 2400 LTSPGGGGKA 2410 KVSGRPSSRK 2420 AKSPAPGLAS 2430 GDRPPSVSSV 2440 HSEGDCNRRT 2450 PLTNRVWEDR 2460 PSSAGSTPFP 2470 YNPLIMRLQA 2480 GVMASPPPPG 2490 LPAGSGPLAG 2500 PHHAWDEEPK 2510 PLLCSQYETL SDSE

Gene Ontology

Classification GO ID Description
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0060633 negative regulation of transcription initiation by RNA polymerase II
Biological Process GO:0010565 regulation of ketone metabolic process
Biological Process GO:0032355 response to estradiol
Cellular Component GO:0000785 chromatin
Cellular Component GO:0016020 membrane
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0005112 Notch binding
Molecular Function GO:0035259 nuclear glucocorticoid receptor binding
Molecular Function GO:0046965 nuclear retinoid X receptor binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0021549 cerebellum development
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0044849 estrous cycle
Biological Process GO:0007595 lactation
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:1902894 negative regulation of miRNA transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.