Overview
| Uniprot ID | Q9Y619 |
|---|
| Protein Name | Mitochondrial ornithine transporter 1 |
|---|
| Gene Name | SLC25A15 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 145 |
YEMETSGKIAKSQNT |
| 148 |
ETSGKIAKSQNTVWS |
| 245 |
QVLSMSGKQAGFIRT |
| 36 |
PFDTMKVKMQTFPDL |
Function
Mitochondrial ornithine-citrulline antiporter (Probable) (PubMed:12807890, PubMed:22262851). Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (Probable) (PubMed:12807890, PubMed:22262851). Lysine and arginine are also transported by the antiport mechanism (Probable) (PubMed:12807890). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (By similarity)
Protein Sequence
10
MKSNPAIQAA
20
IDLTAGAAGG
30
TACVLTGQPF
40
DTMKVKMQTF
50
PDLYRGLTDC
60
CLKTYSQVGF
70
RGFYKGTSPA
80
LIANIAENSV
90
LFMCYGFCQQ
100
VVRKVAGLDK
110
QAKLSDLQNA
120
AAGSFASAFA
130
ALVLCPTELV
140
KCRLQTMYEM
150
ETSGKIAKSQ
160
NTVWSVIKSI
170
LRKDGPLGFY
180
HGLSSTLLRE
190
VPGYFFFFGG
200
YELSRSFFAS
210
GRSKDELGPV
220
PLMLSGGVGG
230
ICLWLAVYPV
240
DCIKSRIQVL
250
SMSGKQAGFI
260
RTFINVVKNE
270
GITALYSGLK
280
PTMIRAFPAN
290
GALFLAYEYS
300
RKLMMNQLEA
Y
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0015297 |
antiporter activity |
| Molecular Function |
GO:0061459 |
L-arginine transmembrane transporter activity |
| Molecular Function |
GO:0015189 |
L-lysine transmembrane transporter activity |
| Molecular Function |
GO:0000064 |
L-ornithine transmembrane transporter activity |
| Biological Process |
GO:1903826 |
L-arginine transmembrane transport |
| Biological Process |
GO:1903401 |
L-lysine transmembrane transport |
| Biological Process |
GO:1990575 |
mitochondrial L-ornithine transmembrane transport |
| Biological Process |
GO:0000050 |
urea cycle |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.