Search Results
Overview
| Uniprot ID | Q9Y624 |
|---|---|
| Protein Name | Junctional adhesion molecule A |
| Gene Name | F11R |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 168 | PSEYTWFKDGIVMPT |
Function
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840)
Protein Sequence
10
MGTKAQVERK
20
LLCLFILAIL
30
LCSLALGSVT
40
VHSSEPEVRI
50
PENNPVKLSC
60
AYSGFSSPRV
70
EWKFDQGDTT
80
RLVCYNNKIT
90
ASYEDRVTFL
100
PTGITFKSVT
110
REDTGTYTCM
120
VSEEGGNSYG
130
EVKVKLIVLV
140
PPSKPTVNIP
150
SSATIGNRAV
160
LTCSEQDGSP
170
PSEYTWFKDG
180
IVMPTNPKST
190
RAFSNSSYVL
200
NPTTGELVFD
210
PLSASDTGEY
220
SCEARNGYGT
230
PMTSNAVRME
240
AVERNVGVIV
250
AAVLVTLILL
260
GILVFGIWFA
270
YSRGHFDRTK
280
KGTSSKKVIY
290
SQPSARSEGE
FKQTSSFLV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0070160 | tight junction |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0031032 | actomyosin structure organization |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0090557 | establishment of endothelial intestinal barrier |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0050892 | intestinal absorption |
| Biological Process | GO:0007159 | leukocyte cell-cell adhesion |
| Biological Process | GO:0035633 | maintenance of blood-brain barrier |
| Biological Process | GO:0035683 | memory T cell extravasation |
| Biological Process | GO:0051497 | negative regulation of stress fiber assembly |
| Biological Process | GO:1903142 | positive regulation of establishment of endothelial barrier |
| Biological Process | GO:1901731 | positive regulation of platelet aggregation |
| Biological Process | GO:0035025 | positive regulation of Rho protein signal transduction |
| Biological Process | GO:1902396 | protein localization to bicellular tight junction |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:2000810 | regulation of bicellular tight junction assembly |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0001817 | regulation of cytokine production |
| Biological Process | GO:0051493 | regulation of cytoskeleton organization |
| Biological Process | GO:0090559 | regulation of membrane permeability |
Reference
PMID: N/A