Overview
| Uniprot ID | Q9Y692 |
|---|
| Protein Name | Glucocorticoid modulatory element-binding protein 1 |
|---|
| Gene Name | GMEB1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 182 |
SNTCRSTKFDLLISS |
Function
Acts as a DNA-binding transcriptional regulator involved in modulating the expression of genes responsive to glucocorticoid signaling (PubMed:12702733). Specifically binds AT-rich DNA motifs known as glucocorticoid modulatory elements (GMEs), repressing or enhancing transcription depending on cellular context (PubMed:10894151). Forms heterodimeric complexes with GMEB2, which enhances its DNA-binding specificity and transcriptional activity. This complex plays a critical role in the repression of glucocorticoid receptor (GR/NR3C1) transcriptional activity, acting as a negative modulator of glucocorticoid signaling (PubMed:10894151). Regulates dopamine-enriched midbrain genes, including tyrosine hydroxylase/TH and the dopamine transporter SLC6A3, essential for dopamine signaling (By similarity). Also binds the transferrin receptor promoter. In the cytoplasm, inhibits caspase activation and neuronal apoptosis by stabilizing CFLARL and blocking pro-caspase 8 activation (PubMed:31046799, PubMed:32514408)
Protein Sequence
10
MANAEVSVPV
20
GDVVVVPTEG
30
NEGENPEDTK
40
TQVILQLQPV
50
QQGLFIDGHF
60
YNRIYEAGSE
70
NNTAVVAVET
80
HTIHKIEEGI
90
DTGTIEANED
100
MEIAYPITCG
110
ESKAILLWKK
120
FVCPGINVKC
130
VKFNDQLISP
140
KHFVHLAGKS
150
TLKDWKRAIR
160
LGGIMLRKMM
170
DSGQIDFYQH
180
DKVCSNTCRS
190
TKFDLLISSA
200
RAPVPGQQTS
210
VVQTPTSADG
220
SITQIAISEE
230
SMEEAGLEWN
240
SALTAAVTMA
250
TEEGVKKDSE
260
EISEDTLMFW
270
KGIADVGLME
280
EVVCNIQKEI
290
EELLRGVQQR
300
LIQAPFQVTD
310
AAVLNNVAHT
320
FGLMDTVKKV
330
LDNRRNQVEQ
340
GEEQFLYTLT
350
DLERQLEEQK
360
KQGQDHRLKS
370
QTVQNVVLMP
380
VSTPKPPKRP
390
RLQRPASTTV
400
LSPSPPVQQP
410
QFTVISPITI
420
TPVGQSFSMG
430
NIPVATLSQG
440
SSPVTVHTLP
450
SGPQLFRYAT
460
VVSSAKSSSP
470
DTVTIHPSSS
480
LALLSSTAMQ
490
DGSTLGNMTT
500
MVSPVELVAM
510
ESGLTSAIQA
520
VESTSEDGQT
530
IIEIDPAPDP
540
EAEDTEGKAV
550
ILETELRTEE
560
KVVAEMEEHQ
570
HQVHNVEIVV
LED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0051008 |
Hsp27 protein binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:1990837 |
sequence-specific double-stranded DNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
PMID: N/A