Search Results
Overview
| Uniprot ID | Q9Y696 |
|---|---|
| Protein Name | Chloride intracellular channel protein 4 |
| Gene Name | CLIC4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 199 | LPKLHIVKVVAKKYR |
| 249 | IAYSDVAKRLTK*** |
Function
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0045177 | apical part of cell |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0034707 | chloride channel complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005254 | chloride channel activity |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0006821 | chloride transport |
| Biological Process | GO:0035088 | establishment or maintenance of apical/basal cell polarity |
| Biological Process | GO:0030216 | keratinocyte differentiation |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0051493 | regulation of cytoskeleton organization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.