Search Results
Overview
| Uniprot ID | Q9Y6A4 |
|---|---|
| Protein Name | Cilia- and flagella-associated protein 20 |
| Gene Name | CFAP20 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 190 | LYLPVQNKAKQ**** |
Function
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed:24414207). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0160112 | axonemal B tubule inner sheath |
| Cellular Component | GO:0005879 | axonemal microtubule |
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031514 | motile cilium |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0036126 | sperm flagellum |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:2000147 | positive regulation of cell motility |
| Biological Process | GO:2000253 | positive regulation of feeding behavior |
| Biological Process | GO:0018095 | protein polyglutamylation |
| Biological Process | GO:0060296 | regulation of cilium beat frequency involved in ciliary motility |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.