Overview
| Uniprot ID | Q9Y6C9 |
|---|
| Protein Name | Mitochondrial carrier homolog 2 |
|---|
| Gene Name | MTCH2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 100 |
QHYQESDKGEELGPG |
| 122 |
SSFDHVIKETTREMI |
Function
Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity)
Protein Sequence
10
MADAASQVLL
20
GSGLTILSQP
30
LMYVKVLIQV
40
GYEPLPPTIG
50
RNIFGRQVCQ
60
LPGLFSYAQH
70
IASIDGRRGL
80
FTGLTPRLCS
90
GVLGTVVHGK
100
VLQHYQESDK
110
GEELGPGNVQ
120
KEVSSSFDHV
130
IKETTREMIA
140
RSAATLITHP
150
FHVITLRSMV
160
QFIGRESKYC
170
GLCDSIITIY
180
REEGILGFFA
190
GLVPRLLGDI
200
LSLWLCNSLA
210
YLVNTYALDS
220
GVSTMNEMKS
230
YSQAVTGFFA
240
SMLTYPFVLV
250
SNLMAVNNCG
260
LAGGCPPYSP
270
IYTSWIDCWC
280
MLQKEGNMSR
290
GNSLFFRKVP
300
FGKTYCCDLK
MLI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0032977 |
membrane insertase activity |
| Biological Process |
GO:0055088 |
lipid homeostasis |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:2000738 |
positive regulation of stem cell differentiation |
| Biological Process |
GO:0045040 |
protein insertion into mitochondrial outer membrane |
| Biological Process |
GO:0070585 |
protein localization to mitochondrion |
| Biological Process |
GO:0010635 |
regulation of mitochondrial fusion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.