Overview
| Uniprot ID | Q9Y6E0 |
|---|
| Protein Name | Serine/threonine-protein kinase 24 |
|---|
| Gene Name | STK24 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 292 |
FILRNAKKTSYLTEL |
Function
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753)
Protein Sequence
10
MDSRAQLWGL
20
ALNKRRATLP
30
HPGGSTNLKA
40
DPEELFTKLE
50
KIGKGSFGEV
60
FKGIDNRTQK
70
VVAIKIIDLE
80
EAEDEIEDIQ
90
QEITVLSQCD
100
SPYVTKYYGS
110
YLKDTKLWII
120
MEYLGGGSAL
130
DLLEPGPLDE
140
TQIATILREI
150
LKGLDYLHSE
160
KKIHRDIKAA
170
NVLLSEHGEV
180
KLADFGVAGQ
190
LTDTQIKRNT
200
FVGTPFWMAP
210
EVIKQSAYDS
220
KADIWSLGIT
230
AIELARGEPP
240
HSELHPMKVL
250
FLIPKNNPPT
260
LEGNYSKPLK
270
EFVEACLNKE
280
PSFRPTAKEL
290
LKHKFILRNA
300
KKTSYLTELI
310
DRYKRWKAEQ
320
SHDDSSSEDS
330
DAETDGQASG
340
GSDSGDWIFT
350
IREKDPKNLE
360
NGALQPSDLD
370
RNKMKDIPKR
380
PFSQCLSTII
390
SPLFAELKEK
400
SQACGGNLGS
410
IEELRGAIYL
420
AEEACPGISD
430
TMVAQLVQRL
440
QRYSLSGGGT
SSH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0090443 |
FAR/SIN/STRIPAK complex |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0004672 |
protein kinase activity |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Biological Process |
GO:0034599 |
cellular response to oxidative stress |
| Biological Process |
GO:0009267 |
cellular response to starvation |
| Biological Process |
GO:0097194 |
execution phase of apoptosis |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0008631 |
intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process |
GO:0030336 |
negative regulation of cell migration |
| Biological Process |
GO:0046777 |
protein autophosphorylation |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0048679 |
regulation of axon regeneration |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.