Search Results

Overview

Uniprot IDQ9Y6E2
Protein NameeIF5-mimic protein 1
Gene NameBZW2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
24 RKRDEKEKFEPTVFR
3 *****MNKHQKPVLT
310 NAVEWNKKEELVAEQ
6 **MNKHQKPVLTGQR

Function

Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931)

Protein Sequence

10 MNKHQKPVLT 20 GQRFKTRKRD 30 EKEKFEPTVF 40 RDTLVQGLNE 50 AGDDLEAVAK 60 FLDSTGSRLD 70 YRRYADTLFD 80 ILVAGSMLAP 90 GGTRIDDGDK 100 TKMTNHCVFS 110 ANEDHETIRN 120 YAQVFNKLIR 130 RYKYLEKAFE 140 DEMKKLLLFL 150 KAFSETEQTK 160 LAMLSGILLG 170 NGTLPATILT 180 SLFTDSLVKE 190 GIAASFAVKL 200 FKAWMAEKDA 210 NSVTSSLRKA 220 NLDKRLLELF 230 PVNRQSVDHF 240 AKYFTDAGLK 250 ELSDFLRVQQ 260 SLGTRKELQK 270 ELQERLSQEC 280 PIKEVVLYVK 290 EEMKRNDLPE 300 TAVIGLLWTC 310 IMNAVEWNKK 320 EELVAEQALK 330 HLKQYAPLLA 340 VFSSQGQSEL 350 ILLQKVQEYC 360 YDNIHFMKAF 370 QKIVVLFYKA 380 DVLSEEAILK 390 WYKEAHVAKG 400 KSVFLDQMKK 410 FVEWLQNAEE ESESEGEEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Molecular Function GO:0045296 cadherin binding
Biological Process GO:0006446 regulation of translational initiation

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.