Search Results
Overview
| Uniprot ID | Q9Y6G9 |
|---|---|
| Protein Name | Cytoplasmic dynein 1 light intermediate chain 1 |
| Gene Name | DYNC1LI1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 385 | KLQSLLAKQPPTAAG |
| 428 | SPIPAGSKKIDPNMK |
| 429 | PIPAGSKKIDPNMKA |
| 486 | GLPPSTKKSGQKPVL |
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005868 | cytoplasmic dynein complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030666 | endocytic vesicle membrane |
| Cellular Component | GO:0101003 | ficolin-1-rich granule membrane |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0001673 | male germ cell nucleus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Cellular Component | GO:0030667 | secretory granule membrane |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0045504 | dynein heavy chain binding |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0061502 | early endosome to recycling endosome transport |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0007018 | microtubule-based movement |
| Biological Process | GO:0032388 | positive regulation of intracellular transport |
| Biological Process | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| Biological Process | GO:0060627 | regulation of vesicle-mediated transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.