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Overview

Uniprot IDQ9Y6H5
Protein NameSynphilin-1
Gene NameSNCAIP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
327 KSILNIVKEGQISLL

Function

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1

Protein Sequence

10 MEAPEYLDLD 20 EIDFSDDISY 30 SVTSLKTIPE 40 LCRRCDTQNE 50 DRSVSSSSWN 60 CGISTLITNT 70 QKPTGIADVY 80 SKFRPVKRVS 90 PLKHQPETLE 100 NNESDDQKNQ 110 KVVEYQKGGE 120 SDLGPQPQEL 130 GPGDGVGGPP 140 GKSSEPSTSL 150 GELEHYDLDM 160 DEILDVPYIK 170 SSQQLASFTK 180 VTSEKRILGL 190 CTTINGLSGK 200 ACSTGSSESS 210 SSNMAPFCVL 220 SPVKSPHLRK 230 ASAVIHDQHK 240 LSTEETEISP 250 PLVKCGSAYE 260 PENQSKDFLN 270 KTFSDPHGRK 280 VEKTTPDCQL 290 RAFHLQSSAA 300 ESKPEEQVSG 310 LNRTSSQGPE 320 ERSEYLKKVK 330 SILNIVKEGQ 340 ISLLPHLAAD 350 NLDKIHDENG 360 NNLLHIAASQ 370 GHAECLQHLT 380 SLMGEDCLNE 390 RNTEKLTPAG 400 LAIKNGQLEC 410 VRWMVSETEA 420 IAELSCSKDF 430 PSLIHYAGCY 440 GQEKILLWLL 450 QFMQEQGISL 460 DEVDQDGNSA 470 VHVASQHGYL 480 GCIQTLVEYG 490 ANVTMQNHAG 500 EKPSQSAERQ 510 GHTLCSRYLV 520 VVETCMSLAS 530 QVVKLTKQLK 540 EQTVERVTLQ 550 NQLQQFLEAQ 560 KSEGKSLPSS 570 PSSPSSPASR 580 KSQWKSPDAD 590 DDSVAKSKPG 600 VQEGIQVLGS 610 LSASSRARPK 620 AKDEDSDKIL 630 RQLLGKEISE 640 NVCTQEKLSL 650 EFQDAQASSR 660 NSKKIPLEKR 670 ELKLARLRQL 680 MQRSLSESDT 690 DSNNSEDPKT 700 TPVRKADRPR 710 PQPIVESVES 720 MDSAESLHLM 730 IKKHTLASGG 740 RRFPFSIKAS 750 KSLDGHSPSP 760 TSESSEPDLE 770 SQYPGSGSIP 780 PNQPSGDPQQ 790 PSPDSTAAQK 800 VATSPKSALK 810 SPSSKRRTSQ 820 NLKLRVTFEE 830 PVVQMEQPSL 840 ELNGEKDKDK 850 GRTLQRTSTS 860 NESGDQLKRP 870 FGAFRSIMET 880 LSGNQNNNNN 890 YQAANQLKTS 900 TLPLTSLGRK 910 TDAKGNPASS ASKGKNKAA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0008219 cell death
Biological Process GO:0042417 dopamine metabolic process
Biological Process GO:0090083 regulation of inclusion body assembly
Biological Process GO:0046928 regulation of neurotransmitter secretion
Cellular Component GO:0043025 neuronal cell body

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.