Search Results
Overview
| Uniprot ID | Q9Y6I3 |
|---|---|
| Protein Name | Epsin-1 |
| Gene Name | EPN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | SSLRRQMKNIVHNYS |
Function
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078)
Protein Sequence
10
MSTSSLRRQM
20
KNIVHNYSEA
30
EIKVREATSN
40
DPWGPSSSLM
50
SEIADLTYNV
60
VAFSEIMSMI
70
WKRLNDHGKN
80
WRHVYKAMTL
90
MEYLIKTGSE
100
RVSQQCKENM
110
YAVQTLKDFQ
120
YVDRDGKDQG
130
VNVREKAKQL
140
VALLRDEDRL
150
REERAHALKT
160
KEKLAQTATA
170
SSAAVGSGPP
180
PEAEQAWPQS
190
SGEEELQLQL
200
ALAMSKEEAD
210
QPPSCGPEDD
220
AQLQLALSLS
230
REEHDKEERI
240
RRGDDLRLQM
250
AIEESKRETG
260
GKEESSLMDL
270
ADVFTAPAPA
280
PTTDPWGGPA
290
PMAAAVPTAA
300
PTSDPWGGPP
310
VPPAADPWGG
320
PAPTPASGDP
330
WRPAAPAGPS
340
VDPWGGTPAP
350
AAGEGPTPDP
360
WGSSDGGVPV
370
SGPSASDPWT
380
PAPAFSDPWG
390
GSPAKPSTNG
400
TTAAGGFDTE
410
PDEFSDFDRL
420
RTALPTSGSS
430
AGELELLAGE
440
VPARSPGAFD
450
MSGVRGSLAE
460
AVGSPPPAAT
470
PTPTPPTRKT
480
PESFLGPNAA
490
LVDLDSLVSR
500
PGPTPPGAKA
510
SNPFLPGGGP
520
ATGPSVTNPF
530
QPAPPATLTL
540
NQLRLSPVPP
550
VPGAPPTYIS
560
PLGGGPGLPP
570
MMPPGPPAPN
TNPFLL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030125 | clathrin vesicle coat |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0140313 | molecular sequestering activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:1903671 | negative regulation of sprouting angiogenesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.