Search Results

Overview

Uniprot IDQ9Y6N5
Protein NameSulfide:quinone oxidoreductase, mitochondrial
Gene NameSQOR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
125 VTELNPDKNCIHTDD
135 IHTDDDEKISYRYLI
155 QLDYEKIKGLPEGFA
173 IGSNYSVKTVEKTWK
241 GAIFGVKKYADALQE
260 RNLTVNYKKNLIEVR
261 NLTVNYKKNLIEVRA
365 RTISVIMKNQTPTKK
372 KNQTPTKKYDGYTSC
65 MAARMKRKVGAENVA

Function

Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro) (PubMed:22852582). It is believed the in vivo electron acceptor is glutathione (PubMed:25225291, PubMed:29715001)

Protein Sequence

10 MVPLVAVVSG 20 PRAQLFACLL 30 RLGTQQVGPL 40 QLHTGASHAA 50 RNHYEVLVLG 60 GGSGGITMAA 70 RMKRKVGAEN 80 VAIVEPSERH 90 FYQPIWTLVG 100 AGAKQLSSSG 110 RPTASVIPSG 120 VEWIKARVTE 130 LNPDKNCIHT 140 DDDEKISYRY 150 LIIALGIQLD 160 YEKIKGLPEG 170 FAHPKIGSNY 180 SVKTVEKTWK 190 ALQDFKEGNA 200 IFTFPNTPVK 210 CAGAPQKIMY 220 LSEAYFRKTG 230 KRSKANIIFN 240 TSLGAIFGVK 250 KYADALQEII 260 QERNLTVNYK 270 KNLIEVRADK 280 QEAVFENLDK 290 PGETQVISYE 300 MLHVTPPMSP 310 PDVLKTSPVA 320 DAAGWVDVDK 330 ETLQHRRYPN 340 VFGIGDCTNL 350 PTSKTAAAVA 360 AQSGILDRTI 370 SVIMKNQTPT 380 KKYDGYTSCP 390 LVTGYNRVIL 400 AEFDYKAEPL 410 ETFPFDQSKE 420 RLSMYLMKAD 430 LMPFLYWNMM 440 LRGYWGGPAF 450 LRKLFHLGMS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0071949 FAD binding
Molecular Function GO:0106436 glutathione-dependent sulfide quinone oxidoreductase activity
Molecular Function GO:0048038 quinone binding
Molecular Function GO:0070224 sulfide:quinone oxidoreductase activity
Biological Process GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.