Search Results

Overview

Uniprot ID	Q9Y6Q9
Protein Name	Nuclear receptor coactivator 3
Gene Name	NCOA3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
19	ASDSRKRKLPCDTPG
620	LESKGHKKLLQLLTC

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit

Protein Sequence

10 MSGLGENLDP 20 LASDSRKRKL 30 PCDTPGQGLT 40 CSGEKRRREQ 50 ESKYIEELAE 60 LISANLSDID 70 NFNVKPDKCA 80 ILKETVRQIR 90 QIKEQGKTIS 100 NDDDVQKADV 110 SSTGQGVIDK 120 DSLGPLLLQA 130 LDGFLFVVNR 140 DGNIVFVSEN 150 VTQYLQYKQE 160 DLVNTSVYNI 170 LHEEDRKDFL 180 KNLPKSTVNG 190 VSWTNETQRQ 200 KSHTFNCRML 210 MKTPHDILED 220 INASPEMRQR 230 YETMQCFALS 240 QPRAMMEEGE 250 DLQSCMICVA 260 RRITTGERTF 270 PSNPESFITR 280 HDLSGKVVNI 290 DTNSLRSSMR 300 PGFEDIIRRC 310 IQRFFSLNDG 320 QSWSQKRHYQ 330 EAYLNGHAET 340 PVYRFSLADG 350 TIVTAQTKSK 360 LFRNPVTNDR 370 HGFVSTHFLQ 380 REQNGYRPNP 390 NPVGQGIRPP 400 MAGCNSSVGG 410 MSMSPNQGLQ 420 MPSSRAYGLA 430 DPSTTGQMSG 440 ARYGGSSNIA 450 SLTPGPGMQS 460 PSSYQNNNYG 470 LNMSSPPHGS 480 PGLAPNQQNI 490 MISPRNRGSP 500 KIASHQFSPV 510 AGVHSPMASS 520 GNTGNHSFSS 530 SSLSALQAIS 540 EGVGTSLLST 550 LSSPGPKLDN 560 SPNMNITQPS 570 KVSNQDSKSP 580 LGFYCDQNPV 590 ESSMCQSNSR 600 DHLSDKESKE 610 SSVEGAENQR 620 GPLESKGHKK 630 LLQLLTCSSD 640 DRGHSSLTNS 650 PLDSSCKESS 660 VSVTSPSGVS 670 SSTSGGVSST 680 SNMHGSLLQE 690 KHRILHKLLQ 700 NGNSPAEVAK 710 ITAEATGKDT 720 SSITSCGDGN 730 VVKQEQLSPK 740 KKENNALLRY 750 LLDRDDPSDA 760 LSKELQPQVE 770 GVDNKMSQCT 780 SSTIPSSSQE 790 KDPKIKTETS 800 EEGSGDLDNL 810 DAILGDLTSS 820 DFYNNSISSN 830 GSHLGTKQQV 840 FQGTNSLGLK 850 SSQSVQSIRP 860 PYNRAVSLDS 870 PVSVGSSPPV 880 KNISAFPMLP 890 KQPMLGGNPR 900 MMDSQENYGS 910 SMGGPNRNVT 920 VTQTPSSGDW 930 GLPNSKAGRM 940 EPMNSNSMGR 950 PGGDYNTSLP 960 RPALGGSIPT 970 LPLRSNSIPG 980 ARPVLQQQQQ 990 MLQMRPGEIP 1000 MGMGANPYGQ 1010 AAASNQLGSW 1020 PDGMLSMEQV 1030 SHGTQNRPLL 1040 RNSLDDLVGP 1050 PSNLEGQSDE 1060 RALLDQLHTL 1070 LSNTDATGLE 1080 EIDRALGIPE 1090 LVNQGQALEP 1100 KQDAFQGQEA 1110 AVMMDQKAGL 1120 YGQTYPAQGP 1130 PMQGGFHLQG 1140 QSPSFNSMMN 1150 QMNQQGNFPL 1160 QGMHPRANIM 1170 RPRTNTPKQL 1180 RMQLQQRLQG 1190 QQFLNQSRQA 1200 LELKMENPTA 1210 GGAAVMRPMM 1220 QPQVSSQQGF 1230 LNAQMVAQRS 1240 RELLSHHFRQ 1250 QRVAMMMQQQ 1260 QQQQQQQQQQ 1270 QQQQQQQQQQ 1280 QQQQQQTQAF 1290 SPPPNVTASP 1300 SMDGLLAGPT 1310 MPQAPPQQFP 1320 YQPNYGMGQQ 1330 PDPAFGRVSS 1340 PPNAMMSSRM 1350 GPSQNPMMQH 1360 PQAASIYQSS 1370 EMKGWPSGNL 1380 ARNSSFSQQQ 1390 FAHQGNPAVY 1400 SMVHMNGSSG 1410 HMGQMNMNPM 1420 PMSGMPMGPD QKYC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0097718	disordered domain specific binding
Molecular Function	GO:0004402	histone acetyltransferase activity
Molecular Function	GO:0016922	nuclear receptor binding
Molecular Function	GO:0046966	nuclear thyroid hormone receptor binding
Molecular Function	GO:0046983	protein dimerization activity
Molecular Function	GO:0000993	RNA polymerase II complex binding
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0043697	cell dedifferentiation
Biological Process	GO:0071392	cellular response to estradiol stimulus
Biological Process	GO:0032870	cellular response to hormone stimulus
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation
Biological Process	GO:1902459	positive regulation of stem cell population maintenance
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:2000035	regulation of stem cell division
Biological Process	GO:0048384	retinoic acid receptor signaling pathway
Biological Process	GO:0070561	vitamin D receptor signaling pathway

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.