Search Results

Overview

Uniprot IDQ9Y6V0
Protein NameProtein piccolo
Gene NamePCLO
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1165 KKQEQEVKTEAEKVI
192 SQEETTKKQKVVQKE
194 EETTKKQKVVQKEQG

Function

Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity)

Protein Sequence

10 MGNEASLEGE 20 GLPEGLAAAA 30 AAGGGASGAG 40 SPSHTAIPAG 50 MEADLSQLSE 60 EERRQIAAVM 70 SRAQGLPKGS 80 VPPAAAESPS 90 MHRKQELDSS 100 HPPKQSGRPP 110 DPGRPAQPGL 120 SKSRTTDTFR 130 SEQKLPGRSP 140 STISLKESKS 150 RTDLKEEHKS 160 SMMPGFLSEV 170 NALSAVSSVV 180 NKFNPFDLIS 190 DSEASQEETT 200 KKQKVVQKEQ 210 GKPEGIIKPP 220 LQQQPPKPIP 230 KQQGPGRDPL 240 QQDGTPKSIS 250 SQQPEKIKSQ 260 PPGTGKPIQG 270 PTQTPQTDHA 280 KLPLQRDASR 290 PQTKQADIVR 300 GESVKPSLPS 310 PSKPPIQQPT 320 PGKPPAQQPG 330 HEKSQPGPAK 340 PPAQPSGLTK 350 PLAQQPGTVK 360 PPVQPPGTTK 370 PPAQPLGPAK 380 PPAQQTGSEK 390 PSSEQPGPKA 400 LAQPPGVGKT 410 PAQQPGPAKP 420 PTQQVGTPKP 430 LAQQPGLQSP 440 AKAPGPTKTP 450 VQQPGPGKIP 460 AQQAGPGKTS 470 AQQTGPTKPP 480 SQLPGPAKPP 490 PQQPGPAKPP 500 PQQPGSAKPP 510 SQQPGSTKPP 520 PQQPGPAKPS 530 PQQPGSTKPP 540 SQQPGSAKPS 550 AQQPSPAKPS 560 AQQSTKPVSQ 570 TGSGKPLQPP 580 TVSPSAKQPP 590 SQGLPKTICP 600 LCNTTELLLH 610 VPEKANFNTC 620 TECQTTVCSL 630 CGFNPNPHLT 640 EVKEWLCLNC 650 QMKRALGGDL 660 APVPSSPQPK 670 LKTAPVTTTS 680 AVSKSSPQPQ 690 QTSPKKDAAP 700 KQDLSKAPEP 710 KKPPPLVKQP 720 TLHGSPSAKA 730 KQPPEADSLS 740 KPAPPKEPSV 750 PSEQDKAPVA 760 DDKPKQPKMV 770 KPTTDLVSSS 780 SATTKPDIPS 790 SKVQSQAEEK 800 TTPPLKTDSA 810 KPSQSFPPTG 820 EKVSPFDSKA 830 IPRPASDSKI 840 ISHPGPSSES 850 KGQKQVDPVQ 860 KKEEPKKAQT 870 KMSPKPDAKP 880 MPKGSPTPPG 890 PRPTAGQTVP 900 TPQQSPKPQE 910 QSRRFSLNLG 920 SITDAPKSQP 930 TTPQETVTGK 940 LFGFGASIFS 950 QASNLISTAG 960 QPGPHSQSGP 970 GAPMKQAPAP 980 SQPPTSQGPP 990 KSTGQAPPAP 1000 AKSIPVKKET 1010 KAPAAEKLEP 1020 KAEQAPTVKR 1030 TETEKKPPPI 1040 KDSKSLTAEP 1050 QKAVLPTKLE 1060 KSPKPESTCP 1070 LCKTELNIGS 1080 KDPPNFNTCT 1090 ECKNQVCNLC 1100 GFNPTPHLTE 1110 IQEWLCLNCQ 1120 TQRAISGQLG 1130 DIRKMPPAPS 1140 GPKASPMPVP 1150 TESSSQKTAV 1160 PPQVKLVKKQ 1170 EQEVKTEAEK 1180 VILEKVKETL 1190 SMEKIPPMVT 1200 TDQKQEESKL 1210 EKDKASALQE 1220 KKPLPEEKKL 1230 IPEEEKIRSE 1240 EKKPLLEEKK 1250 PTPEDKKLLP 1260 EAKTSAPEEQ 1270 KHDLLKSQVQ 1280 IAEEKLEGRV 1290 APKTVQEGKQ 1300 PQTKMEGLPS 1310 GTPQSLPKED 1320 DKTTKTIKEQ 1330 PQPPCTAKPD 1340 QVEPGKEKTE 1350 KEDDKSDTSS 1360 SQQPKSPQGL 1370 SDTGYSSDGI 1380 SSSLGEIPSL 1390 IPTDEKDILK 1400 GLKKDSFSQE 1410 SSPSSPSDLA 1420 KLESTVLSIL 1430 EAQASTLADE 1440 KSEKKTQPHE 1450 VSPEQPKDQE 1460 KTQSLSETLE 1470 ITISEEEIKE 1480 SQEERKDTFK 1490 KDSQQDIPSS 1500 KDHKEKSEFV 1510 DDITTRREPY 1520 DSVEESSESE 1530 NSPVPQRKRR 1540 TSVGSSSSDE 1550 YKQEDSQGSG 1560 EEEDFIRKQI 1570 IEMSADEDAS 1580 GSEDDEFIRN 1590 QLKEISSSTE 1600 SQKKEETKGK 1610 GKITAGKHRR 1620 LTRKSSTSID 1630 EDAGRRHSWH 1640 DEDDEAFDES 1650 PELKYRETKS 1660 QESEELVVTG 1670 GGGLRRFKTI 1680 ELNSTIADKY 1690 SAESSQKKTS 1700 LYFDEEPELE 1710 MESLTDSPED 1720 RSRGEGSSSL 1730 HASSFTPGTS 1740 PTSVSSLDED 1750 SDSSPSHKKG 1760 ESKQQRKARH 1770 RPHGPLLPTI 1780 EDSSEEEELR 1790 EEEELLKEQE 1800 KQREIEQQQR 1810 KSSSKKSKKD 1820 KDELRAQRRR 1830 ERPKTPPSNL 1840 SPIEDASPTE 1850 ELRQAAEMEE 1860 LHRSSCSEYS 1870 PSIESDPEGF 1880 EISPEKIIEV 1890 QKVYKLPTAV 1900 SLYSPTDEQS 1910 IMQKEGSQKA 1920 LKSAEEMYEE 1930 MMHKTHKYKA 1940 FPAANERDEV 1950 FEKEPLYGGM 1960 LIEDYIYESL 1970 VEDTYNGSVD 1980 GSLLTRQEEE 1990 NGFMQQKGRE 2000 QKIRLSEQIY 2010 EDPMQKITDL 2020 QKEFYELESL 2030 HSVVPQEDIV 2040 SSSFIIPESH 2050 EIVDLGTMVT 2060 STEEERKLLD 2070 ADAAYEELMK 2080 RQQMQLTPGS 2090 SPTQAPIGED 2100 MTESTMDFDR 2110 MPDASLTSSV 2120 LSGASLTDST 2130 SSATLSIPDV 2140 KITQHFSTEE 2150 IEDEYVTDYT 2160 REIQEIIAHE 2170 SLILTYSEPS 2180 ESATSVPPSD 2190 TPSLTSSVSS 2200 VCTTDSSSPI 2210 TTLDSITTVY 2220 TEPVDMITKF 2230 EDSEEISSST 2240 YFPGSIIDYP 2250 EEISVSLDRT 2260 APPDGRASAD 2270 HIVISLSDMA 2280 SSIIESVVPK 2290 PEGPVADTVS 2300 TDLLISEKDP 2310 VKKAKKETGN 2320 GIILEVLEAY 2330 RDKKELEAER 2340 TKSSLSETVF 2350 DHPPSSVIAL 2360 PMKEQLSTTY 2370 FTSGETFGQE 2380 KPASQLPSGS 2390 PSVSSLPAKP 2400 RPFFRSSSLD 2410 ISAQPPPPPP 2420 PPPPPPPPPP 2430 PPPPPPLPPP 2440 TSPKPTILPK 2450 KKLTVASPVT 2460 TATPLFDAVT 2470 TLETTAVLRS 2480 NGLPVTRICT 2490 TAPPPVPPKP 2500 SSIPSGLVFT 2510 HRPEPSKPPI 2520 APKPVIPQLP 2530 TTTQKPTDIH 2540 PKPTGLSLTS 2550 SMTLNLVTSA 2560 DYKLPSPTSP 2570 LSPHSNKSSP 2580 RFSKSLTETY 2590 VVITLPSEPG 2600 TPTDSSASQA 2610 ITSWPLGSPS 2620 KDLVSVEPVF 2630 SVVPPVTAVE 2640 IPISSEQTFY 2650 ISGALQTFSA 2660 TPVTAPSSFQ 2670 AAPTSVTQFL 2680 TTEVSKTEVS 2690 ATRSTAPSVG 2700 LSSISITIPP 2710 EPLALDNIHL 2720 EKPQYKEDGK 2730 LQLVGDVIDL 2740 RTVPKVEVKT 2750 TDKCIDLSAS 2760 TMDVKRQITA 2770 NEVYGKQISA 2780 VQPSIINLSV 2790 TSSIVTPVSL 2800 ATETVTFVTC 2810 TASASYTTGT 2820 ESLVGAEHAM 2830 TTPLQLTTSK 2840 HAEPPYRIPS 2850 DQVFPIAREE 2860 APINLSLGTP 2870 AHAVTLAITK 2880 PVTVPPVGVT 2890 NGWTDSTVSQ 2900 GITDGEVVDL 2910 STTKSHRTVV 2920 TMDESTSSVM 2930 TKIIEDEKPV 2940 DLTAGRRAVC 2950 CDVVYKLPFG 2960 RSCTAQQPAT 2970 TLPEDRFGYR 2980 DDHYQYDRSG 2990 PYGYRGIGGM 3000 KPSMSDTNLA 3010 EAGHFFYKSK 3020 NAFDYSEGTD 3030 TAVDLTSGRV 3040 TTGEVMDYSS 3050 KTTGPYPETR 3060 QVISGAGIST 3070 PQYSTARMTP 3080 PPGPQYCVGS 3090 VLRSSNGVVY 3100 SSVATPTPST 3110 FAITTQPGSI 3120 FSTTVRDLSG 3130 IHTADAVTSL 3140 PAMHHSQPMP 3150 RSYFITTGAS 3160 ETDIAVTGID 3170 ISASLQTITM 3180 ESLTAETIDS 3190 VPTLTTASEV 3200 FPEVVGDESA 3210 LLIVPEEDKQ 3220 QQQLDLEREL 3230 LELEKIKQQR 3240 FAEELEWERQ 3250 EIQRFREQEK 3260 IMVQKKLEEL 3270 QSMKQHLLFQ 3280 QEEERQAQFM 3290 MRQETLAQQQ 3300 LQLEQIQQLQ 3310 QQLHQQLEEQ 3320 KIRQIYQYNY 3330 DPSGTASPQT 3340 TTEQAILEGQ 3350 YAALEGSQFW 3360 ATEDATTTAS 3370 AVVAIEIPQS 3380 QGWYTVQSDG 3390 VTQYIAPPGI 3400 LSTVSEIPLT 3410 DVVVKEEKQP 3420 KKRSSGAKVR 3430 GQYDDMGENM 3440 TDDPRSFKKI 3450 VDSGVQTDDE 3460 DATDRSYVSR 3470 RRRTKKSVDT 3480 SVQTDDEDQD 3490 EWDMPTRSRR 3500 KARVGKYGDS 3510 MTEADKTKPL 3520 SKVSSIAVQT 3530 VAEISVQTEP 3540 VGTIRTPSIR 3550 ARVDAKVEII 3560 KHISAPEKTY 3570 KGGSLGCQTE 3580 ADSDTQSPQY 3590 LSATSPPKDK 3600 KRPTPLEIGY 3610 SSHLRADSTV 3620 QLAPSPPKSP 3630 KVLYSPISPL 3640 SPGKALESAF 3650 VPYEKPLPDD 3660 ISPQKVLHPD 3670 MAKVPPASPK 3680 TAKMMQRSMS 3690 DPKPLSPTAD 3700 ESSRAPFQYT 3710 EGYTTKGSQT 3720 MTSSGAQKKV 3730 KRTLPNPPPE 3740 EISTGTQSTF 3750 STMGTVSRRR 3760 ICRTNTMARA 3770 KILQDIDREL 3780 DLVERESAKL 3790 RKKQAELDEE 3800 EKEIDAKLRY 3810 LEMGINRRKE 3820 ALLKEREKRE 3830 RAYLQGVAED 3840 RDYMSDSEVS 3850 STRPTRIESQ 3860 HGIERPRTAP 3870 QTEFSQFIPP 3880 QTQTESQLVP 3890 PTSPYTQYQY 3900 SSPALPTQAP 3910 TSYTQQSHFE 3920 QQTLYHQQVS 3930 PYQTQPTFQA 3940 VATMSFTPQV 3950 QPTPTPQPSY 3960 QLPSQMMVIQ 3970 QKPRQTTLYL 3980 EPKITSNYEV 3990 IRNQPLMIAP 4000 VSTDNTFAVS 4010 HLGSKYNSLD 4020 LRIGLEERSS 4030 MASSPISSIS 4040 ADSFYADIDH 4050 HTPRNYVLID 4060 DIGEITKGTA 4070 ALSTAFSLHE 4080 KDLSKTDRLL 4090 RTTETRRSQE 4100 VTDFLAPLQS 4110 SSRLHSYVKA 4120 EEDPMEDPYE 4130 LKLLKHQIKQ 4140 EFRRGTESLD 4150 HLAGLSHYYH 4160 ADTSYRHFPK 4170 SEKYSISRLT 4180 LEKQAAKQLP 4190 AAILYQKQSK 4200 HKKSLIDPKM 4210 SKFSPIQESR 4220 DLEPDYSSYM 4230 TSSTSSIGGI 4240 SSRARLLQDD 4250 ITFGLRKNIT 4260 DQQKFMGSSL 4270 GTGLGTLGNT 4280 IRSALQDEAD 4290 KPYSSGSRSR 4300 PSSRPSSVYG 4310 LDLSIKRDSS 4320 SSSLRLKAQE 4330 AEALDVSFSH 4340 ASSSARTKPT 4350 SLPISQSRGR 4360 IPIVAQNSEE 4370 ESPLSPVGQP 4380 MGMARAAAGP 4390 LPPISADTRD 4400 QFGSSHSLPE 4410 VQQHMREESR 4420 TRGYDRDIAF 4430 IMDDFQHAMS 4440 DSEAYHLRRE 4450 ETDWFDKPRE 4460 SRLENGHGLD 4470 RKLPERLVHS 4480 RPLSQHQEQI 4490 IQMNGKTMHY 4500 IFPHARIKIT 4510 RDSKDHTVSG 4520 NGLGIRIVGG 4530 KEIPGHSGEI 4540 GAYIAKILPG 4550 GSAEQTGKLM 4560 EGMQVLEWNG 4570 IPLTSKTYEE 4580 VQSIISQQSG 4590 EAEICVRLDL 4600 NMLSDSENSQ 4610 HLELHEPPKA 4620 VDKAKSPGVD 4630 PKQLAAELQK 4640 VSLQQSPLVL 4650 SSVVEKGSHV 4660 HSGPTSAGSS 4670 SVPSPGQPGS 4680 PSVSKKKHGS 4690 SKPTDGTKVV 4700 SHPITGEIQL 4710 QINYDLGNLI 4720 IHILQARNLV 4730 PRDNNGYSDP 4740 FVKVYLLPGR 4750 GQVMVVQNAS 4760 AEYKRRTKHV 4770 QKSLNPEWNQ 4780 TVIYKSISME 4790 QLKKKTLEVT 4800 VWDYDRFSSN 4810 DFLGEVLIDL 4820 SSTSHLDNTP 4830 RWYPLKEQTE 4840 SIDHGKSHSS 4850 QSSQQSPKPS 4860 VIKSRSHGIF 4870 PDPSKDMQVP 4880 TIEKSHSSPG 4890 SSKSSSEGHL 4900 RSHGPSRSQS 4910 KTSVTQTHLE 4920 DAGAAIAAAE 4930 AAVQQLRIQP 4940 TKPPNHRPAE 4950 SSVSTGSSGS 4960 SFGSGYSVDS 4970 EGSSSTAGET 4980 NLFPIPRIGK 4990 MGQNGQEPVK 5000 QPGVGVGLAD 5010 TEAKTQVMGE 5020 IKIALKKEMK 5030 TDGEQLIVEI 5040 LQCRNITYKF 5050 KSPDHLPDLY 5060 VKIYVMNIST 5070 QKKVIKKKTR 5080 VCRHDREPSF 5090 NETFRFSLSP 5100 AGHSLQILLF 5110 SNGGKFMKKT 5120 LIGEACIWLD 5130 KVDLRKRIVN 5140 WHKLLVSPTQ TH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0048788 cytoskeleton of presynaptic active zone
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098982 GABA-ergic synapse
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0045202 synapse
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0005522 profilin binding
Molecular Function GO:0098882 structural constituent of presynaptic active zone
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0099140 presynaptic actin cytoskeleton organization
Biological Process GO:1904071 presynaptic active zone assembly
Biological Process GO:0035418 protein localization to synapse
Biological Process GO:0051049 regulation of transport
Biological Process GO:0097091 synaptic vesicle clustering
Biological Process GO:0016079 synaptic vesicle exocytosis

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.