Search Results
Overview
| Uniprot ID | Q9Y6W5 |
|---|---|
| Protein Name | Actin-binding protein WASF2 |
| Gene Name | WASF2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 290 | GSGLAGPKRSSVVSP |
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex
Protein Sequence
10
MPLVTRNIEP
20
RHLCRQTLPS
30
VRSELECVTN
40
ITLANVIRQL
50
GSLSKYAEDI
60
FGELFTQANT
70
FASRVSSLAE
80
RVDRLQVKVT
90
QLDPKEEEVS
100
LQGINTRKAF
110
RSSTIQDQKL
120
FDRNSLPVPV
130
LETYNTCDTP
140
PPLNNLTPYR
150
DDGKEALKFY
160
TDPSYFFDLW
170
KEKMLQDTKD
180
IMKEKRKHRK
190
EKKDNPNRGN
200
VNPRKIKTRK
210
EEWEKMKMGQ
220
EFVESKEKLG
230
TSGYPPTLVY
240
QNGSIGCVEN
250
VDASSYPPPP
260
QSDSASSPSP
270
SFSEDNLPPP
280
PAEFSYPVDN
290
QRGSGLAGPK
300
RSSVVSPSHP
310
PPAPPLGSPP
320
GPKPGFAPPP
330
APPPPPPPMI
340
GIPPPPPPVG
350
FGSPGTPPPP
360
SPPSFPPHPD
370
FAAPPPPPPP
380
PAADYPTLPP
390
PPLSQPTGGA
400
PPPPPPPPPP
410
GPPPPPFTGA
420
DGQPAIPPPL
430
SDTTKPKSSL
440
PAVSDARSDL
450
LSAIRQGFQL
460
RRVEEQREQE
470
KRDVVGNDVA
480
TILSRRIAVE
490
YSDSEDDSSE
FDEDDWSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0031209 | SCAR complex |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0071933 | Arp2/3 complex binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0051018 | protein kinase A binding |
| Molecular Function | GO:0034237 | protein kinase A regulatory subunit binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0051497 | negative regulation of stress fiber assembly |
| Biological Process | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0098974 | postsynaptic actin cytoskeleton organization |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.