Search Results

Overview

Uniprot IDQ9Y6X8
Protein NameZinc fingers and homeoboxes protein 2
Gene NameZHX2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
33 EVDRAKEKGIGTPQP
532 YPDFAPQKFKEKTQG
6 **MASKRKSTTPCMV
73 MGESQSKKLQGGYEC
732 DVVPQYYKDPKKLCE
736 QYYKDPKKLCEEDLE

Function

Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity)

Protein Sequence

10 MASKRKSTTP 20 CMVRTSQVVE 30 QDVPEEVDRA 40 KEKGIGTPQP 50 DVAKDSWAAE 60 LENSSKENEV 70 IEVKSMGESQ 80 SKKLQGGYEC 90 KYCPYSTQNL 100 NEFTEHVDMQ 110 HPNVILNPLY 120 VCAECNFTTK 130 KYDSLSDHNS 140 KFHPGEANFK 150 LKLIKRNNQT 160 VLEQSIETTN 170 HVVSITTSGP 180 GTGDSDSGIS 190 VSKTPIMKPG 200 KPKADAKKVP 210 KKPEEITPEN 220 HVEGTARLVT 230 DTAEILSRLG 240 GVELLQDTLG 250 HVMPSVQLPP 260 NINLVPKVPV 270 PLNTTKYNSA 280 LDTNATMINS 290 FNKFPYPTQA 300 ELSWLTAASK 310 HPEEHIRIWF 320 ATQRLKHGIS 330 WSPEEVEEAR 340 KKMFNGTIQS 350 VPPTITVLPA 360 QLAPTKVTQP 370 ILQTALPCQI 380 LGQTSLVLTQ 390 VTSGSTTVSC 400 SPITLAVAGV 410 TNHGQKRPLV 420 TPQAAPEPKR 430 PHIAQVPEPP 440 PKVANPPLTP 450 ASDRKKTKEQ 460 IAHLKASFLQ 470 SQFPDDAEVY 480 RLIEVTGLAR 490 SEIKKWFSDH 500 RYRCQRGIVH 510 ITSESLAKDQ 520 LAIAASRHGR 530 TYHAYPDFAP 540 QKFKEKTQGQ 550 VKILEDSFLK 560 SSFPTQAELD 570 RLRVETKLSR 580 REIDSWFSER 590 RKLRDSMEQA 600 VLDSMGSGKK 610 GQDVGAPNGA 620 LSRLDQLSGA 630 QLTSSLPSPS 640 PAIAKSQEQV 650 HLLRSTFART 660 QWPTPQEYDQ 670 LAAKTGLVRT 680 EIVRWFKENR 690 CLLKTGTVKW 700 MEQYQHQPMA 710 DDHGYDAVAR 720 KATKPMAESP 730 KNGGDVVPQY 740 YKDPKKLCEE 750 DLEKLVTRVK 760 VGSEPAKDCL 770 PAKPSEATSD 780 RSEGSSRDGQ 790 GSDENEESSV 800 VDYVEVTVGE 810 EDAISDRSDS 820 WSQAAAEGVS 830 ELAESDSDCV PAEAGQA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0060040 retinal bipolar neuron differentiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.