Overview
| Uniprot ID | Q9Y6Y0 |
|---|
| Protein Name | Influenza virus NS1A-binding protein |
|---|
| Gene Name | IVNS1ABP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 103 |
KADKELVKDVYSAAK |
Function
Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). May play a role in mRNA nuclear export (PubMed:30538201)
Protein Sequence
10
MIPNGYLMFE
20
DENFIESSVA
30
KLNALRKSGQ
40
FCDVRLQVCG
50
HEMLAHRAVL
60
ACCSPYLFEI
70
FNSDSDPHGI
80
SHVKFDDLNP
90
EAVEVLLNYA
100
YTAQLKADKE
110
LVKDVYSAAK
120
KLKMDRVKQV
130
CGDYLLSRMD
140
VTSCISYRNF
150
ASCMGDSRLL
160
NKVDAYIQEH
170
LLQISEEEEF
180
LKLPRLKLEV
190
MLEDNVCLPS
200
NGKLYTKVIN
210
WVQRSIWENG
220
DSLEELMEEV
230
QTLYYSADHK
240
LLDGNLLDGQ
250
AEVFGSDDDH
260
IQFVQKKPPR
270
ENGHKQISSS
280
STGCLSSPNA
290
TVQSPKHEWK
300
IVASEKTSNN
310
TYLCLAVLDG
320
IFCVIFLHGR
330
NSPQSSPTST
340
PKLSKSLSFE
350
MQQDELIEKP
360
MSPMQYARSG
370
LGTAEMNGKL
380
IAAGGYNREE
390
CLRTVECYNP
400
HTDHWSFLAP
410
MRTPRARFQM
420
AVLMGQLYVV
430
GGSNGHSDDL
440
SCGEMYDSNI
450
DDWIPVPELR
460
TNRCNAGVCA
470
LNGKLYIVGG
480
SDPYGQKGLK
490
NCDVFDPVTK
500
LWTSCAPLNI
510
RRHQSAVCEL
520
GGYLYIIGGA
530
ESWNCLNTVE
540
RYNPENNTWT
550
LIAPMNVARR
560
GAGVAVLNGK
570
LFVCGGFDGS
580
HAISCVEMYD
590
PTRNEWKMMG
600
NMTSPRSNAG
610
IATVGNTIYA
620
VGGFDGNEFL
630
NTVEVYNLES
640
NEWSPYTKIF
QF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031463 |
Cul3-RING ubiquitin ligase complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Cellular Component |
GO:0005667 |
transcription regulator complex |
| Molecular Function |
GO:1990756 |
ubiquitin-like ligase-substrate adaptor activity |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0031397 |
negative regulation of protein ubiquitination |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0009615 |
response to virus |
| Biological Process |
GO:0008380 |
RNA splicing |
| Biological Process |
GO:0006383 |
transcription by RNA polymerase III |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.