Search Results
Overview
| Uniprot ID | Q9Z1F9 |
|---|---|
| Protein Name | SUMO-activating enzyme subunit 2 |
| Gene Name | Uba2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 611 | DDKARKRKLEENEAA |
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity)
Protein Sequence
10
MALSRGLPRE
20
LAEAVSGGRV
30
LVVGAGGIGC
40
ELLKNLVLTG
50
FSHIDLIDLD
60
TIDVSNLNRQ
70
FLFQKKHVGR
80
SKAQVAKESV
90
LQFHPQANIE
100
AHHDSIMNPD
110
YNVEFFRQFI
120
LVMNALDNRA
130
ARNHVNRMCL
140
AADVPLIESG
150
TAGYLGQVTT
160
IKKGVTECYE
170
CHPKPTQRTF
180
PGCTIRNTPS
190
EPIHCIVWAK
200
YLFNQLFGEE
210
DADQEVSPDR
220
ADPEAAWEPT
230
EAEARARASN
240
EDGDIKRIST
250
KEWAKSTGYD
260
PVKLFTKLFK
270
DDIRYLLTMD
280
KLWRKRKPPV
290
PLDWAEVQSQ
300
GEANADQQNE
310
PQLGLKDQQV
320
LDVKSYASLF
330
SKSIETLRVH
340
LAEKGDGAEL
350
IWDKDDPPAM
360
DFVTSAANLR
370
MHIFSMNMKS
380
RFDIKSMAGN
390
IIPAIATTNA
400
VIAGLIVLEG
410
LKILSGKIDQ
420
CRTIFLNKQP
430
NPRKKLLVPC
440
ALDPPNTNCY
450
VCASKPEVTV
460
RLNVHKVTVL
470
TLQDKIVKEK
480
FAMVAPDVQI
490
EDGKGTILIS
500
SEEGETEANN
510
PKKLSDFGIR
520
NGSRLQADDF
530
LQDYTLLINI
540
LHSEDLGKDV
550
EFEVVGDSPE
560
KVGPKQAEDA
570
AKSIANGSDD
580
GAQPSTSTAQ
590
EQDDVLIVDS
600
DEEGPSNSTD
610
CSGDDKARKR
620
KLEENEAAST
630
KKCRLEQMED
PDDVIALD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0031510 | SUMO activating enzyme complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0044388 | small protein activating enzyme binding |
| Molecular Function | GO:0019948 | SUMO activating enzyme activity |
| Molecular Function | GO:0032183 | SUMO binding |
| Molecular Function | GO:0016740 | transferase activity |
| Molecular Function | GO:0044390 | ubiquitin-like protein conjugating enzyme binding |
| Biological Process | GO:0033235 | positive regulation of protein sumoylation |
| Biological Process | GO:0016925 | protein sumoylation |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.