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Overview

Uniprot ID	Q9Z204
Protein Name	Heterogeneous nuclear ribonucleoproteins C1/C2
Gene Name	Hnrnpc
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
8	MASNVTNKTDPRSMN

Function

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing

Protein Sequence

10 MASNVTNKTD 20 PRSMNSRVFI 30 GNLNTLVVKK 40 SDVEAIFSKY 50 GKIVGCSVHK 60 GFAFVQYVNE 70 RNARAAVAGE 80 DGRMIAGQVL 90 DINLAAEPKV 100 NRGKAGVKRS 110 AAEMYGSVPE 120 HPSPSPLLSS 130 SFDLDYDFQR 140 DYYDRMYSYP 150 ARVPPPPPIA 160 RAVVPSKRQR 170 VSGNTSRRGK 180 SGFNSKSGQR 190 GSSSKSGKLK 200 GDDLQAIKKE 210 LTQIKQKVDS 220 LLESLEKIEK 230 EQSKQADLSF 240 SSPVEMKNEK 250 SEEEQSSASV 260 KKDETNVKME 270 SEAGADDSAE 280 EGDLLDDDDN 290 EDRGDDQLEL 300 KDDEKEPEEG 310 EDDRDSANGE DDS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0071013	catalytic step 2 spliceosome
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:1990826	nucleoplasmic periphery of the nuclear pore complex
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0045120	pronucleus
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0005681	spliceosomal complex
Cellular Component	GO:0005697	telomerase holoenzyme complex
Molecular Function	GO:1990827	deaminase binding
Molecular Function	GO:0004857	enzyme inhibitor activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003730	mRNA 3'-UTR binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:1990247	N6-methyladenosine-containing RNA reader activity
Molecular Function	GO:0008266	poly(U) RNA binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0043021	ribonucleoprotein complex binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0070034	telomerase RNA binding
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:0090367	negative regulation of mRNA modification

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.