Search Results
Overview
| Uniprot ID | Q9Z2D6 |
|---|---|
| Protein Name | Methyl-CpG-binding protein 2 |
| Gene Name | Mecp2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 210 | ASEGVQVKRVLEKSP |
| 271 | IPKKRGRKPGSVVAA |
| 304 | HETVLPIKKRKTRET |
| 447 | TTTTVAEKYKHRGEG |
Function
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC)
Protein Sequence
10
MVAGMLGLRE
20
EKSEDQDLQG
30
LRDKPLKFKK
40
AKKDKKEDKE
50
GKHEPLQPSA
60
HHSAEPAEAG
70
KAETSESSGS
80
APAVPEASAS
90
PKQRRSIIRD
100
RGPMYDDPTL
110
PEGWTRKLKQ
120
RKSGRSAGKY
130
DVYLINPQGK
140
AFRSKVELIA
150
YFEKVGDTSL
160
DPNDFDFTVT
170
GRGSPSRREQ
180
KPPKKPKSPK
190
APGTGRGRGR
200
PKGSGTGRPK
210
AAASEGVQVK
220
RVLEKSPGKL
230
VVKMPFQASP
240
GGKGEGGGAT
250
TSAQVMVIKR
260
PGRKRKAEAD
270
PQAIPKKRGR
280
KPGSVVAAAA
290
AEAKKKAVKE
300
SSIRSVHETV
310
LPIKKRKTRE
320
TVSIEVKEVV
330
KPLLVSTLGE
340
KSGKGLKTCK
350
SPGRKSKESS
360
PKGRSSSASS
370
PPKKEHHHHH
380
HHSESTKAPM
390
PLLPSPPPPE
400
PESSEDPISP
410
PEPQDLSSSI
420
CKEEKMPRGG
430
SLESDGCPKE
440
PAKTQPMVAT
450
TTTVAEKYKH
460
RGEGERKDIV
470
SSSMPRPNRE
480
EPVDSRTPVT
ERVS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003676 | nucleic acid binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0035197 | siRNA binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0045322 | unmethylated CpG binding |
| Biological Process | GO:0008344 | adult locomotory behavior |
| Biological Process | GO:0008306 | associative learning |
| Biological Process | GO:0001662 | behavioral fear response |
| Biological Process | GO:0006576 | biogenic amine metabolic process |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0032048 | cardiolipin metabolic process |
| Biological Process | GO:0071317 | cellular response to isoquinoline alkaloid |
| Biological Process | GO:0035865 | cellular response to potassium ion |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0016358 | dendrite development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0040029 | epigenetic regulation of gene expression |
| Biological Process | GO:0060079 | excitatory postsynaptic potential |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0071514 | genomic imprinting |
| Biological Process | GO:0008211 | glucocorticoid metabolic process |
| Biological Process | GO:0006541 | glutamine metabolic process |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0006020 | inositol metabolic process |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0007616 | long-term memory |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0033555 | multicellular organismal response to stress |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0048712 | negative regulation of astrocyte differentiation |
| Biological Process | GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| Biological Process | GO:1903860 | negative regulation of dendrite extension |
| Biological Process | GO:0061000 | negative regulation of dendritic spine development |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0044027 | negative regulation of gene expression via chromosomal CpG island methylation |
| Biological Process | GO:0090327 | negative regulation of locomotion involved in locomotory behavior |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:2000635 | negative regulation of primary miRNA processing |
| Biological Process | GO:1903941 | negative regulation of respiratory gaseous exchange |
| Biological Process | GO:0051151 | negative regulation of smooth muscle cell differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001976 | nervous system process involved in regulation of systemic arterial blood pressure |
| Biological Process | GO:0050905 | neuromuscular process |
| Biological Process | GO:0050884 | neuromuscular process controlling posture |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0042551 | neuron maturation |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0007219 | Notch signaling pathway |
| Biological Process | GO:0046470 | phosphatidylcholine metabolic process |
| Biological Process | GO:1901953 | positive regulation of anterograde dense core granule transport |
| Biological Process | GO:1905492 | positive regulation of branching morphogenesis of a nerve |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:1903861 | positive regulation of dendrite extension |
| Biological Process | GO:0060999 | positive regulation of dendritic spine development |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0090063 | positive regulation of microtubule nucleation |
| Biological Process | GO:1901956 | positive regulation of retrograde dense core granule transport |
| Biological Process | GO:0031915 | positive regulation of synaptic plasticity |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0009791 | post-embryonic development |
| Biological Process | GO:0019230 | proprioception |
| Biological Process | GO:0099611 | regulation of action potential firing threshold |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0002087 | regulation of respiratory gaseous exchange by nervous system process |
| Biological Process | GO:0050807 | regulation of synapse organization |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007585 | respiratory gaseous exchange by respiratory system |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0051707 | response to other organism |
| Biological Process | GO:0019233 | sensory perception of pain |
| Biological Process | GO:0050975 | sensory perception of touch |
| Biological Process | GO:0035176 | social behavior |
| Biological Process | GO:0001964 | startle response |
| Biological Process | GO:0007416 | synapse assembly |
| Biological Process | GO:0006641 | triglyceride metabolic process |
| Biological Process | GO:0021591 | ventricular system development |
| Biological Process | GO:0008542 | visual learning |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0010385 | double-stranded methylated DNA binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0000400 | four-way junction DNA binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0140566 | histone reader activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008327 | methyl-CpG binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.