Search Results

Overview

Uniprot IDQ9Z2I0
Protein NameMitochondrial proton/calcium exchanger protein
Gene NameLetm1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
132 SLKDKNKKLEEGGPV
458 VAEVEGEKVDNKAKL
591 EIKKELSKTGEEKYI
596 LSKTGEEKYIEESAA
605 IEESAASKRLSKRVQ

Function

Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:23716663, PubMed:27669901). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:23716663, PubMed:27669901). Functions also as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). Essential for early embryonic development (PubMed:23716663)

Protein Sequence

10 MASILLRSCR 20 GRGPARLAPP 30 RAASPRGSLR 40 DRACLSCTRT 50 LGLTSRESVL 60 SRCCTPAHPV 70 YLCFKGEPLS 80 CWTQRPECQG 90 TAARTTWTPA 100 SARLVVTGPQ 110 YLPVRGWHSS 120 SPLGEDSVIE 130 KSLKSLKDKN 140 KKLEEGGPVY 150 SPPAQVVVRK 160 SLGQKVLDEL 170 RHYYHGFRLL 180 WIDTKIAARM 190 LWRILNGHTL 200 TRRERRQFLR 210 ICADLFRLVP 220 FLVFVVVPFM 230 EFLLPVVVKL 240 FPNMLPSTFE 250 TQSIKEERLK 260 KELRVKLELA 270 KFLQDTIEEM 280 ALKNKAAKGN 290 ATKDFSAFFQ 300 KIRETGERPS 310 NEEIMRFSKL 320 FEDELTLDNL 330 TRPQLVALCK 340 LLELQSIGTN 350 NFLRFQLTMR 360 LRSIKADDKL 370 ISEEGVDSLT 380 VKELQAACRA 390 RGMRALGVTE 400 DRLKGQLKQW 410 LDLHLHHEIP 420 TSLLILSRAM 430 YLPDTLSPAD 440 QLKSTLQTLP 450 EIVAKEAQVK 460 VAEVEGEKVD 470 NKAKLEATLQ 480 EEAAIQQEHL 490 EELKRASEAV 500 KDIQPEVAEA 510 TLPGRPGPEP 520 QPPVDDVILP 530 SEVLTDTAPV 540 LEGLKGEEIT 550 KEEIDILSDA 560 CSKLQEQKKS 570 LTKEKEELEL 580 LKEDVQDYSE 590 DLQEIKKELS 600 KTGEEKYIEE 610 SAASKRLSKR 620 VQQMIGQIDG 630 LITQLETTQQ 640 DGKLGPSQST 650 PTGESVISIT 660 ELISAMKQIK 670 HIPEHKLISL 680 TSALDDNKDG 690 NINIDDLVKV 700 IDLVNKEDVQ 710 ISTTQVAEIV 720 ATLEKEEKIE 730 EKEKAKEKAE KEAAEVKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0015369 calcium:proton antiporter activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0043022 ribosome binding
Biological Process GO:0099093 calcium export from the mitochondrion
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0042407 cristae formation
Biological Process GO:0007007 inner mitochondrial membrane organization
Biological Process GO:0051560 mitochondrial calcium ion homeostasis
Biological Process GO:0006851 mitochondrial calcium ion transmembrane transport
Biological Process GO:0140141 mitochondrial potassium ion transmembrane transport
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0051562 negative regulation of mitochondrial calcium ion concentration
Biological Process GO:0034214 protein hexamerization
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:1900069 regulation of cellular hyperosmotic salinity response

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.