Search Results

Overview

Uniprot IDQ9Z2I8
Protein NameSuccinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Gene NameSuclg2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
109 KGGVHLTKDPKVVGE
48 LQEYQSKKLMSEHGV
67 FFVANTAKEALEAAK
74 KEALEAAKRLNAKEI
94 ILAGGRGKGVFNSGL

Function

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as a GTP-specific itaconyl- and malyl-CoA synthetase

Protein Sequence

10 MASPVAIAAQ 20 AGKLLRERAL 30 RPLLAVRSQA 40 GHLTPRRWLN 50 LQEYQSKKLM 60 SEHGVRVQRF 70 FVANTAKEAL 80 EAAKRLNAKE 90 IVLKAQILAG 100 GRGKGVFNSG 110 LKGGVHLTKD 120 PKVVGELAQQ 130 MIGYNLATKQ 140 TPKEGVKVNK 150 VMVAEALDIS 160 RETYLAILMD 170 RSHNGPVIVG 180 SPQGGVDIEE 190 VAASSPELIF 200 KEQIDIFEGI 210 KDSQAQRMAE 220 NLGFLGSLKN 230 QAADQITKLY 240 HLFLKIDATQ 250 VEVNPFGETP 260 EGQVVCFDAK 270 INFDDNAEFR 280 QKDIFAMDDK 290 SENEPIENEA 300 ARYDLKYIGL 310 DGNIACFVNG 320 AGLAMATCDI 330 IFLNGGKPAN 340 FLDLGGGVKE 350 AQVYEAFKLL 360 TSDPKVEAIL 370 VNIFGGIVNC 380 AIIANGITKA 390 CRELELKVPL 400 VVRLEGTNVQ 410 EAQNILKSSG 420 LPITSAVDLE 430 DAAKKAVASV AKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0042709 succinate-CoA ligase complex
Cellular Component GO:0045244 succinate-CoA ligase complex (GDP-forming)
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0019003 GDP binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0004776 succinate-CoA ligase (GDP-forming) activity
Molecular Function GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity
Biological Process GO:0006105 succinate metabolic process
Biological Process GO:0006104 succinyl-CoA metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.