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Overview

Uniprot IDQ9Z2I9
Protein NameSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Gene NameSucla2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
108 VLAGGRGKGTFTSGL
116 GTFTSGLKGGVKIVF
120 SGLKGGVKIVFSPEE
129 VFSPEEAKAVSSQMI
139 SSQMIGQKLITKQTG
143 IGQKLITKQTGEKGR
215 IDIVEGIKKEQAVTL
216 DIVEGIKKEQAVTLA
287 NSAYRQKKIFDLQDW
368 FKLITSDKKVQAILV
417 GTRVDDAKALIADSG
78 VPKGFVAKSSDEAYA
88 DEAYAIAKKLGSKDV
93 IAKKLGSKDVVIKAQ

Function

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase

Protein Sequence

10 MAASMFYGRQ 20 LAAAALRSHR 30 PQTTLRAAAQ 40 VLGNSGLFNK 50 HGLQVQQQQQ 60 RTLSLHEYLS 70 MELLQEAGVS 80 VPKGFVAKSS 90 DEAYAIAKKL 100 GSKDVVIKAQ 110 VLAGGRGKGT 120 FTSGLKGGVK 130 IVFSPEEAKA 140 VSSQMIGQKL 150 ITKQTGEKGR 160 ICNQVLVCER 170 KYPRREYYFA 180 ITMERSFQGP 190 VLIGSAQGGV 200 NIEDVAAENP 210 EAIVKEPIDI 220 VEGIKKEQAV 230 TLAQKMGFPS 240 NIVDSAAENM 250 IKLYNLFLKY 260 DATMVEINPM 270 VEDSDGKVLC 280 MDAKINFDSN 290 SAYRQKKIFD 300 LQDWSQEDER 310 DKEAANADIN 320 YIGLDGSIGC 330 LVNGAGLAMA 340 TMDIIKLHGG 350 TPANFLDVGG 360 GATVQQVTEA 370 FKLITSDKKV 380 QAILVNIFGG 390 IMRCDVIAQG 400 IVMAVKDLEI 410 RIPVVVRLQG 420 TRVDDAKALI 430 ADSGLKILAC 440 DDLDEAAKMV 450 VKLSEIVTLA 460 KEAHVDVKFQ LPI

Gene Ontology

Classification GO ID Description
Cellular Component GO:1902494 catalytic complex
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0042709 succinate-CoA ligase complex
Cellular Component GO:0009361 succinate-CoA ligase complex (ADP-forming)
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0050074 malate-CoA ligase activity
Molecular Function GO:0004775 succinate-CoA ligase (ADP-forming) activity
Molecular Function GO:0004774 succinate-CoA ligase activity
Biological Process GO:0006108 malate metabolic process
Biological Process GO:0006105 succinate metabolic process
Biological Process GO:0006104 succinyl-CoA metabolic process
Biological Process GO:0110052 toxic metabolite repair
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.