Search Results
Overview
| Uniprot ID | V9HVY3 |
|---|---|
| Protein Name | Protein disulfide-isomerase |
| Gene Name | HEL-S-269 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 61 | APWCGHCKRLAPEYE |
Function
Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity
Protein Sequence
10
MRLRRLALFP
20
GVALLLAAAR
30
LAAASDVLEL
40
TDDNFESRIS
50
DTGSAGLMLV
60
EFFAPWCGHC
70
KRLAPEYEAA
80
ATRLKGIVPL
90
AKVDCTANTN
100
TCNKYGVSGY
110
PTLKIFRDGE
120
EAGAYDGPRT
130
ADGIVSHLKK
140
QAGPASVPLR
150
TEEEFKKFIS
160
DKDASIVGFF
170
DDSFSEAHSE
180
FLKAASNLRD
190
NYRFAHTNVE
200
SLVNEYDDNG
210
EGIILFRPSH
220
LTNKFEDKTV
230
AYTEQKMTSG
240
KIKKFIQENI
250
FGICPHMTED
260
NKDLIQGKDL
270
LIAYYDVDYE
280
KNAKGSNYWR
290
NRVMMVAKKF
300
LDAGHKLNFA
310
VASRKTFSHE
320
LSDFGLESTA
330
GEIPVVAIRT
340
AKGEKFVMQE
350
EFSRDGKALE
360
RFLQDYFDGN
370
LKRYLKSEPI
380
PESNDGPVKV
390
VVAENFDEIV
400
NNENKDVLIE
410
FYAPWCGHCK
420
NLEPKYKELG
430
EKLSKDPNIV
440
IAKMDATAND
450
VPSPYEVRGF
460
PTIYFSPANK
470
KLNPKKYEGG
480
RELSDFISYL
490
QREATNPPVI
500
QEEKPKKKKK
AQEDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0042470 | melanosome |
| Molecular Function | GO:0106222 | lncRNA binding |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
| Molecular Function | GO:0015035 | protein-disulfide reductase activity |
Reference
PMID: N/A